diff --git a/requirements.txt b/requirements.txt
index 4634e68c3fba5aa5ea23b4252b762cb09469db26..a90f7b36406ef11dc417e5a82c27544d787ecb08 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -8,5 +8,6 @@ pyBigWig
 # pybedtools @ git+https://github.com/blaiseli/pybedtools.git@fix_missing_headers --global-option="cythonize"
 pybedtools @ git+https://github.com/blaiseli/pybedtools.git@pep518
 # pybedtools
-scipy<=1.3.3
+# scipy<=1.3.3
+scipy>=1.4.2
 seaborn
diff --git a/setup.py b/setup.py
index 1523c839acd75054aef1ada34d27ef74060d24ff..a447a3041a1fdb59c17d7f7fa68c5a950c82af63 100644
--- a/setup.py
+++ b/setup.py
@@ -46,7 +46,8 @@ setup(
         "pyBigWig",
         "pybedtools @ git+https://github.com/blaiseli/pybedtools.git@pep518",
         # "pybedtools",
-        "scipy<=1.3.3",
+        # "scipy<=1.3.3",
+        "scipy>=1.4.2",
         "seaborn"],
     # specific versions and index would rather belong to requirements.txt
     #dependency_links=["git+https://gitlab.pasteur.fr/bli/libworkflows@744dd79b579577cb6e131653260d7990946be3ad#egg=libworkflows-0.1"],