From da655dd38fe444c918ac754206568ad39e03be45 Mon Sep 17 00:00:00 2001 From: David Bikard <dbikard@gmail.com> Date: Sun, 13 May 2018 22:19:04 +0200 Subject: [PATCH] updates --- README.md | 5 ++--- 1 file changed, 2 insertions(+), 3 deletions(-) diff --git a/README.md b/README.md index 98ba29d..bef73e9 100644 --- a/README.md +++ b/README.md @@ -10,9 +10,8 @@ contains an average of 19 targets per gene. A pool of guide RNAs obtained throug oligo synthesis was cloned under the control of a constitutive promoter on plasmid psgRNA and electroporated in strain LC-E18 carrying the dCas9 gene under the control of a Ptet promoter in the chromosome. The pooled library of cells was then grown in rich medium -over 17 generations with anhydrotetracycline (aTc). The effect of each guide on the cell fitness can be measured as -the fold change in abundance (log2FC) of the guide RNA in the library -during the course of the experiment, as measured through deep sequencing of the library. +over 17 generations with anhydrotetracycline (aTc). The fold change in abundance (log2FC) of the guide RNA +was measured through deep sequencing of the library. The log2FC data for all guides in the screen can be found in the file screen_data.csv -- GitLab