diff --git a/README.md b/README.md
index 6d59701aedbb8a8eb543a4c32fa5f7e8f02c1383..ab8a079453d9aae7210501f8abf1865267f20be0 100644
--- a/README.md
+++ b/README.md
@@ -2,7 +2,33 @@
 
 Tools to design and analyse CRISPRi experiments
 
-## API
+## Getting Started
+
+### Installation
+
+For the moment, you can install this package only via PyPI
+
+#### PyPI
+
+```console
+$ pip install crisprbact
+$ crisprbact --help
+```
+
+```
+Usage: crisprbact [OPTIONS] COMMAND [ARGS]...
+
+Options:
+  -v, --verbose
+  --help         Show this message and exit.
+
+Commands:
+  predict
+```
+
+### API
+
+Using this library in your python code.
 
 ```python
 from crisprbact import on_target_predict
@@ -14,7 +40,7 @@ for guide_rna in guide_rnas:
 
 ```
 
-outputs :
+_output :_
 
 ```
 {'target': 'TCATCACGGGCCTTCGCCACGCGCG', 'guide': 'TCATCACGGGCCTTCGCCAC', 'start': 82, 'stop': 102, 'pam': 80, 'ori': '-', 'pred': -0.4719254873780802}
@@ -23,9 +49,15 @@ outputs :
 {'target': 'CCTGATCGGTATTGAACAGCATCTG', 'guide': 'CCTGATCGGTATTGAACAGC', 'start': 29, 'stop': 49, 'pam': 27, 'ori': '-', 'pred': 0.23853258873311955}
 ```
 
-## Command-line
+### Command-line
+
+#### Predict guide RNAs activity
 
-### predict guide RNAs activity
+Input the sequence of a target gene and this script will output candidate guide RNAs for the S. pyogenes dCas9 with predicted on-target activity.
+
+```console
+$ crisprbact predict --help
+```
 
 ```
 Usage: crisprbact predict [OPTIONS] COMMAND [ARGS]...
@@ -38,32 +70,55 @@ Commands:
   from-str  Outputs candidate guide RNAs for the S.
 ```
 
-#### From a string sequence:
+##### From a string sequence:
+
+The target input sequence can be a simple string.
+
+```console
+$ crisprbact predict from-str --help
+```
+
 ```
 Usage: crisprbact predict from-str [OPTIONS] [OUTPUT_FILE]
 
   Outputs candidate guide RNAs for the S. pyogenes dCas9 with predicted on-
   target activity from a target gene.
 
-  [OUTPUT_FILE] file where the precitions are saved. Default = "stdout"
+  [OUTPUT_FILE] file where the candidate guide RNAs are saved. Default =
+  "stdout"
 
 Options:
   -t, --target TEXT  [required]
   --help             Show this message and exit.
 ```
 
+```console
+$ crisprbact predict from-str -t ACCACTGGCGTGCGCGTTACTCATCAGATGCTGTTCAATACCGATCAGGTTATCGAAGTGTTTGTGATTGTTTGCCGCGCGCGTGGCGAAGGCCCGTGATGAAGGAAAAGTTTTGCGCTATGTTGGCAATATTGATGAAG guide-rnas.tsv
+```
+
+output file `guide-rnas.tsv` :
+
+No `seq_id` is defined since it is from a simple string.
 
 ```
-crisprbact predict from-str -t ACCACTGGCGTGCGCGTTACTCATCAGATGCTGTTCAATACCGATCAGGTTATCGAAGTGTTTGTGATTGTTTGCCGCGCGCGTGGCGAAGGCCCGTGATGAAGGAAAAGTTTTGCGCTATGTTGGCAATATTGATGAAG guide-rnas.tsv
+target	PAM position	prediction	seq_id
+TCATCACGGGCCTTCGCCACGCGCG	80	-0.4719254873780802	N/A
+CATCACGGGCCTTCGCCACGCGCGC	79	1.0491308060379676	N/A
+CGCGCGCGGCAAACAATCACAAACA	61	-0.9021152826078697	N/A
+CCTGATCGGTATTGAACAGCATCTG	27	0.23853258873311955	N/A
 ```
 
-You can pipe the results :
+You can also pipe the results :
 
-```
-crisprbact predict from-str -t ACCACTGGCGTGCGCGTTACTCATCAGATGCTGTTCAATACCGATCAGGTTATCGAAGTGTTTGTGATTGTTTGCCGCGCGCGTGGCGAAGGCCCGTGATGAAGGAAAAGTTTTGCGCTATGTTGGCAATATTGATGAAG | tail -n +2 | wc -l
+```console
+$ crisprbact predict from-str -t ACCACTGGCGTGCGCGTTACTCATCAGATGCTGTTCAATACCGATCAGGTTATCGAAGTGTTTGTGATTGTTTGCCGCGCGCGTGGCGAAGGCCCGTGATGAAGGAAAAGTTTTGCGCTATGTTGGCAATATTGATGAAG | tail -n +2 | wc -l
 ```
 
-#### From a sequence file
+##### From a sequence file
+
+```console
+$ crisprbact predict from-seq --help
+```
 
 ```
 Usage: crisprbact predict from-seq [OPTIONS] [OUTPUT_FILE]
@@ -71,28 +126,29 @@ Usage: crisprbact predict from-seq [OPTIONS] [OUTPUT_FILE]
   Outputs candidate guide RNAs for the S. pyogenes dCas9 with predicted on-
   target activity from a target gene.
 
-  [OUTPUT_FILE] file where the precitions are saved. Default = "stdout"
+  [OUTPUT_FILE] file where the candidate guide RNAs are saved. Default =
+  "stdout"
 
 Options:
-  -t, --target FILENAME  Sequence file  [required]
-  -f, --seq-format TEXT  Sequence file format
-  --help                 Show this message and exit.
-
+  -t, --target FILENAME           Sequence file  [required]
+  -f, --seq-format [fasta|fa|gb|genbank]
+                                  Sequence file format  [default: fasta]
+  --help                          Show this message and exit.
 ```
 
-- Fasta file (could be multifasta)
+- Fasta file (could be a multifasta file)
 
-```
-poetry run crisprbact predict from-seq -t /tmp/seq.fasta guide-rnas.tsv
+```console
+$ crisprbact predict from-seq -t /tmp/seq.fasta guide-rnas.tsv
 ```
 
 - GenBank file
 
-```
-poetry run crisprbact predict from-seq -t /tmp/seq.gb -f gb guide-rnas.tsv
+```console
+$ crisprbact predict from-seq -t /tmp/seq.gb -f gb guide-rnas.tsv
 ```
 
-### Output file
+##### Output file
 
 ```
 target	PAM position	prediction	input_id