d="m 249.81774,-156.9253 21.02256,0 c 1.51292,0 2.73089,1.2949 2.73089,2.90336 l 0,14.61249 c 0,1.60846 -1.21797,2.90337 -2.73089,2.90337 l -21.02256,0 c -1.51292,0 -2.73089,-1.29491 -2.73089,-2.90337 l 0,-14.61249 c 0,-1.60846 1.21797,-2.90336 2.73089,-2.90336 z"
<h2>Non-Flagellar Type III Secretion Systems in sequenced genomes</h2>
<divid="head">
<imgsrc="images/systeme_complet.png"title="Non-Flagellar Type III Secretion System schema"alt="Non-Flagellar Type III Secretion System schema">
<p>Non-Flagellar Type III Secretion Systems (NF-T3SS, or injectisomes) are bacterial machineries partially homologous to the bacterial flagellum,
which allow direct injection of bacterial effectors from bacterial cytoplasm to eukaryotic cells via a molecular needle (cf. schema above).
NF-T3SS are found in animal and plant pathogens (<spanclass="gene_name">Yersinia pestis</span>,<spanclass="gene_name">Escherichia coli</span>, <spanclass="gene_name">Burkholderia</span>,...),
but also in plant and insect symbionts (e.g., Rhizobiales).</p>
<p>This website allows to query a dataset of 216 NF-T3SS retrieved from 1385 complete genome sequences.
These systems were detected with proteic profiles of NF-T3SS core genes (<spanclass="gene_name">sctC</span>, <spanclass="gene_name">sctN</span>, <spanclass="gene_name">sctJ</span>,
and with an analysis of the genomic context of the hits obtained.
This dataset along with the methodology is described in <ahref="http://www.plosgenetics.org/doi/pgen.1002983">Abby and Rocha 2012</a>.</p>
<p>Proteic profiles used for this study are available to analyze user data on the
Mobyle web server: <ahref="http://mobyle.pasteur.fr/cgi-bin/portal.py#forms::T3SSscan-FLAGscan"target="_blank">http://mobyle.pasteur.fr/cgi-bin/portal.py#forms::T3SSscan-FLAGscan</a>.
These profiles allow to detect both NF-T3SS and flagella.</p>
<ahref="http://www.plosgenetics.org/doi/pgen.1002983"target="_blank"><spanclass="citation_article_title">The Non-Flagellar Type III Secretion System Evolved from the Bacterial Flagellum and Diversified into Host-Cell Adapted Systems.</span></a>