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  - First INPUT could be used for peak calling on all IP to reduce technical variability, but each IP could be associated to a specific INPUT in the design file.
 
 **What if I have no INPUT ?**
-- The pipeline failed to run if no INPUT are done. Following ENCODE guidelines, control experiment must be performed and are used during peak calling.
+- Following ENCODE guidelines, control experiment must be performed and are used during peak calling for ChIp-seq experiments. Nevertheless, the CUT&Tag method reduces the background noise and allows for more precise and sensitive detection of protein-DNA interactions, reducing the need for an input control or IgG control. Follow the CUT&Tag section for more explanation about running ePeak without INPUT.
 
 **What if I have one INPUT for one mark, and two for another ?**
-- Experimental design with different numbers of replicates for IP and/or INPUT are included to ChIPflow. 
+- Experimental design with different numbers of replicates for IP and/or INPUT are included to ePeak. 
 
 **What if I have one replicate for one mark ?**
 - The pipeline will stop after peak calling, without selection of peaks as reproducibility cannot be ensure with only one replicate.