thoeris.md

title: Thoeris

Example of genomic structure

The Thoeris system have been describe in a total of 2 subsystems.

Here is some example found in the RefSeq database:

Thoeris_I subsystem in the genome of Bacillus thuringiensis (GCF_020809205.1) is composed of 2 proteins: ThsA_new_grand (WP_021728720.1)and, ThsB_Global (WP_021728719.1).

Thoeris_II subsystem in the genome of Acinetobacter baumannii (GCF_014672775.1) is composed of 2 proteins: ThsB_Global (WP_000120680.1)and, ThsA_new_petit (WP_005134880.1).

Distribution of the system among prokaryotes

The Thoeris system is present in a total of 286 different species.

Among the 22k complete genomes of RefSeq, this system is present in 812 genomes (3.6 %).

Proportion of genome encoding the Thoeris system for the 14 phyla with more than 50 genomes in the RefSeq database. Pie chart of the repartition of all the subsystems found in the RefSeq database.

Experimental validation

Thoeris systems were experimentally validated using:

A system from Bacillus amyloliquefaciens in Bacillus subtilis has an anti-phage effect against SPO1, SBSphiJ, SBSphiC (Doron et al., 2018)

A system from Bacillus cereus in Bacillus subtilis has an anti-phage effect against phi29, SBSphiC, SPO1, SBSphiJ (Doron et al., 2018; Ofir et al., 2021)

A system from Bacillus dafuensis in Bacillus subtilis has an anti-phage effect against phi3T, SPBeta, SPR, SBSphi11, SBSphi13, phi29, SBSphiJ, SPO1 (Ofir et al., 2021)

Relevant abstracts

::article-doi-list

items: - doi: 10.1038/s41586-021-04098-7 - doi: 10.1126/science.aar4120

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