title: AbiO
layout: article
tableColumns:
article:
doi: 10.1016/j.mib.2005.06.006
abstract: |
Abortive infection (Abi) systems, also called phage exclusion, block phage multiplication and cause premature bacterial cell death upon phage infection. This decreases the number of progeny particles and limits their spread to other cells allowing the bacterial population to survive. Twenty Abi systems have been isolated in Lactococcus lactis, a bacterium used in cheese-making fermentation processes, where phage attacks are of economical importance. Recent insights in their expression and mode of action indicate that, behind diverse phenotypic and molecular effects, lactococcal Abis share common traits with the well-studied Escherichia coli systems Lit and Prr. Abis are widespread in bacteria, and recent analysis indicates that Abis might have additional roles other than conferring phage resistance.
Sensor: Unknown
Activator: Unknown
Effector: Unknown
PFAM: PF01443, PF09848
contributors:
- Florian Tesson
relevantAbstracts:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
- doi: 10.3168/jds.S0022-0302(98)75713-3AbiO
Description
AbiO is a single gene defense system discovered in 1998 :ref{doi=10.3168/jds.S0022-0302(98)75713-3}.
AbiO is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. Even though, their name corresponds to an abortive infection, their mechanism of action does not necessarily correspond to an abortive infection. AbiO is classified as a possible Abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
This system is only composed of one single gene containing a helicase domain.
Molecular mechanism
As far as we are aware, the molecular mechanism is unknown.
Example of genomic structure
The AbiO is composed of 1 protein: AbiO.
Here is an example found in the RefSeq database:
The AbiO system in Pantoea agglomerans (GCF_004117135.1, NZ_CP034477) is composed of 1 protein: AbiO (WP_129063585.1)
Distribution of the system among prokaryotes
Among the 22,803 complete genomes of RefSeq, the AbiO is detected in 100 genomes (0.44 %).
The system was detected in 61 different species.
Proportion of genome encoding the AbiO system for the 14 phyla with more than 50 genomes in the RefSeq database.
Structure
AbiO
Example 1
::molstar-pdbe-plugin
height: 700 dataUrls:
- /abio/AbiO__AbiO.cif
::