-
fltesson authored89180a7b
title: AbiT
layout: article
tableColumns:
article:
doi: 10.1016/j.mib.2005.06.006
abstract: |
Abortive infection (Abi) systems, also called phage exclusion, block phage multiplication and cause premature bacterial cell death upon phage infection. This decreases the number of progeny particles and limits their spread to other cells allowing the bacterial population to survive. Twenty Abi systems have been isolated in Lactococcus lactis, a bacterium used in cheese-making fermentation processes, where phage attacks are of economical importance. Recent insights in their expression and mode of action indicate that, behind diverse phenotypic and molecular effects, lactococcal Abis share common traits with the well-studied Escherichia coli systems Lit and Prr. Abis are widespread in bacteria, and recent analysis indicates that Abis might have additional roles other than conferring phage resistance.
Sensor: Unknown
Activator: Unknown
Effector: Unknown
PFAM: PF18864
contributors:
- Florian Tesson
relevantAbstracts:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
- doi: 10.1128/jb.184.22.6325-6332.2002AbiT
Description
AbiT was discovered in Lactococcus lactis in 2022 :ref{doi=10.1128/jb.184.22.6325-6332.2002}.
AbiT is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. Even though, their name corresponds to abortive infection, their mechanism of action does not necessarily correspond to an abortive infection phenotype. AbiT is classified as an abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
AbiT is composed of two proteins: AbiTi with a transmembrane helix domain and AbiTii.
Molecular mechanism
As far as we are aware, the molecular mechanism is unknown.
Example of genomic structure
The AbiT is composed of 2 proteins: AbiTi and AbiTii.
Here is an example found in the RefSeq database:
The AbiT system in Bdellovibrio bacteriovorus (GCF_000317895.1, NC_019567) is composed of 2 proteins AbiTii (WP_051026283.1) AbiTi (WP_041577337.1)
Distribution of the system among prokaryotes
Among the 22,803 complete genomes of RefSeq, the AbiT is detected in 8 genomes (0.04 %).
The system was detected in 6 different species.
Proportion of genome encoding the AbiT system for the 14 phyla with more than 50 genomes in the RefSeq database.
Structure
AbiT
Example 1
::molstar-pdbe-plugin
height: 700 dataUrls:
- /abit/AbiT.AbiT__AbiTi.0.V.cif
- /abit/AbiT.AbiT__AbiTii.0.V.cif
::