-
mdomingu authorededb5b2cb
title: Gao_Upx
layout: article
tableColumns:
article:
doi: 10.1126/science.aba0372
abstract: |
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements and rely on dedicated antiviral defense systems, such as restriction endonucleases and CRISPR, to survive. The enormous diversity of viruses suggests that more types of defense systems exist than are currently known. By systematic defense gene prediction and heterologous reconstitution, here we discover 29 widespread antiviral gene cassettes, collectively present in 32% of all sequenced bacterial and archaeal genomes, that mediate protection against specific bacteriophages. These systems incorporate enzymatic activities not previously implicated in antiviral defense, including RNA editing and retron satellite DNA synthesis. In addition, we computationally predict a diverse set of other putative defense genes that remain to be characterized. These results highlight an immense array of molecular functions that microbes use against viruses.
Sensor: Unknown
Activator: Unknown
Effector: Unknown
contributors:
- Marian Dominguez-Mirazo
relevantAbstracts:
- doi: 10.1126/science.aba0372Gao_upx
Description
The Gao_upx system is composed by a single protein. It was predicted through a guilty by association approach independent of domain annotations and validated in a heterologous system :ref{doi=10.1126/science.aba0372}. It's been identified as part of a highly conserved core defense hotspot in Pseudomonas aeruginosa strains :ref{doi=10.1093/nar/gkad317}.
Molecular mechanisms
As far as we are aware, the molecular mechanism is unknown.
Example of genomic structure
The Gao_Upx system is composed of one protein: UpxA.
Here is an example found in the RefSeq database:
Gao_Upx system in the genome of Salmonella sp. (GCF_020268625.1) is composed of 1 protein: UpxA (WP_060647174.1).
Distribution of the system among prokaryotes
The Gao_Upx system is present in a total of 31 different species.
Among the 22k complete genomes of RefSeq, this system is present in 39 genomes (0.2 %).
Proportion of genome encoding the Gao_Upx system for the 14 phyla with more than 50 genomes in the RefSeq database.
Structure
Gao_Upx
::molstar-pdbe-plugin
height: 700 dataUrl: /gao_upx/Gao_Upx__UpxA-plddts_90.66658.pdb
::