From 0390f44ba3daebb2c98325dfd31a4e9122ef2b0d Mon Sep 17 00:00:00 2001
From: Lucas PAOLI <lucas.paoli@pasteur.fr>
Date: Wed, 22 Nov 2023 14:44:28 +0100
Subject: [PATCH] Update panchino_gp28.md according to Hackaton guidelines, see
https://gitlab.pasteur.fr/mdm-lab/wiki/-/issues/225
---
content/3.defense-systems/panchino_gp28.md | 29 ++++++++++++++--------
1 file changed, 19 insertions(+), 10 deletions(-)
diff --git a/content/3.defense-systems/panchino_gp28.md b/content/3.defense-systems/panchino_gp28.md
index 8a94f856..4526aea2 100644
--- a/content/3.defense-systems/panchino_gp28.md
+++ b/content/3.defense-systems/panchino_gp28.md
@@ -7,11 +7,29 @@ tableColumns:
abstract: |
Temperate phages are common, and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage. Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defence systems include a single-subunit restriction system, a heterotypic exclusion system and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, which acts as a highly effective counter-defence system. Prophage-mediated viral defence offers an efficient mechanism for bacterial success in host-virus dynamics, and counter-defence promotes phage co-evolution.
PFAM: PF01170, PF02384, PF13588
+contributors:
+ - Lucas Paoli
+relevantAbstracts:
+ - doi: 10.1038/nmicrobiol.2016.251
---
# Panchino_gp28
-## To do
+## Description
+
+The Panchino gp28 defense system was described in Dedrick et al. 2017 :ref{doi=10.1038/nmicrobiol.2016.251} and is named after the Panchino prophage (on which it is located) and the corresponding gene.
+
+## Molecular mechanisms
+
+Panchino gp28 is a restriction system (type I) :ref{doi=10.1038/nmicrobiol.2016.251,10.1016/j.mib.2023.102321}.
+
+## Example of genomic structure
+
+To do
+
+## Distribution of the system among prokaryotes
+
+To do
## Structure
@@ -52,12 +70,3 @@ end
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-## Relevant abstract
-::relevant-abstracts
----
-items:
- - doi: 10.1038/nmicrobiol.2016.251
-
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-::
-
--
GitLab