diff --git a/content/2.general-concepts/Defense systems effectors b/content/2.general-concepts/defense-systems-effectors.md similarity index 100% rename from content/2.general-concepts/Defense systems effectors rename to content/2.general-concepts/defense-systems-effectors.md diff --git a/content/3.defense-systems/detocs.md b/content/3.defense-systems/detocs.md index 72039702035ece976c7e9959daf598031222eb81..5a9a42d35cc06d89f0969f9ebd64bedd3fa94f1a 100644 --- a/content/3.defense-systems/detocs.md +++ b/content/3.defense-systems/detocs.md @@ -8,7 +8,7 @@ tableColumns: During viral infection, cells can deploy immune strategies that deprive viruses of molecules essential for their replication. Here, we report a family of immune effectors in bacteria that, upon phage infection, degrade cellular adenosine triphosphate (ATP) and deoxyadenosine triphosphate (dATP) by cleaving the N-glycosidic bond between the adenine and sugar moieties. These ATP nucleosidase effectors are widely distributed within multiple bacterial defense systems, including cyclic oligonucleotide-based antiviral signaling systems (CBASS), prokaryotic argonautes, and nucleotide-binding leucine-rich repeat (NLR)-like proteins, and we show that ATP and dATP degradation during infection halts phage propagation. By analyzing homologs of the immune ATP nucleosidase domain, we discover and characterize Detocs, a family of bacterial defense systems with a two-component phosphotransfer-signaling architecture. The immune ATP nucleosidase domain is also encoded within diverse eukaryotic proteins with immune-like architectures, and we show biochemically that eukaryotic homologs preserve the ATP nucleosidase activity. Our findings suggest that ATP and dATP degradation is a cell-autonomous innate immune strategy conserved across the tree of life. Sensor: Unknown Activator: Unknown - Effector:Nucleotide modifying + Effector: Nucleotide modifying PFAM: PF01048, PF18742 contributors: - François Rousset