From 0901e467c46a5d6299f5d3678e355d601be7aa71 Mon Sep 17 00:00:00 2001
From: emordret <ernest.mordret@pasteur.fr>
Date: Fri, 15 Dec 2023 18:51:19 +0100
Subject: [PATCH] Update prrc.md
---
content/3.defense-systems/prrc.md | 27 ++++++++++++++++-----------
1 file changed, 16 insertions(+), 11 deletions(-)
diff --git a/content/3.defense-systems/prrc.md b/content/3.defense-systems/prrc.md
index 105acc27..7b51d8f5 100644
--- a/content/3.defense-systems/prrc.md
+++ b/content/3.defense-systems/prrc.md
@@ -10,9 +10,25 @@ tableColumns:
Activator: Direct
Effector: Nucleic acid degrading
PFAM: PF00270, PF02384, PF04313, PF04851, PF12008, PF12161, PF13166, PF18766
+contributors:
+ - Ernest Mordret
+relevant abstracts:
+ - doi: 10.1186/1743-422X-7-360
+ - doi: 10.1006/jmbi.1995.0343
---
# PrrC
+
+## Description
+
+The PrrC system protects bacteria against phages via an abortive infection. It is composed of a single effector protein, but relies on the presence of a full type Ic restriction-modification system in the vicinity. PrrC proteins are therefore typically found embedded in a larger RM system.
+
+## Molecular mechanism
+The effector protein prrC complements a RM system by cutting tRNALys in the anticodon loop, upstream of the wobble nucleotide and causes the arrest of phage protein synthesis and phage growth.
+prrC serves as a guardian of the acrivity of EcoprrI, which can be inactivated by the Stp peptide of phage T4 at the beginning of infection. Inactivation of EcoprrI by Stp induces a conformation change that in turn activates PrrC, releasing its nuclease activity and stalling host and phage growth :ref{doi=10.1006/jmbi.1995.0343}.
+Because it sabotages the host's translation machinery, prrC is considered to be an abortive infection system.
+
+
## Example of genomic structure
The PrrC system is composed of 4 proteins: EcoprrI, Type_I_S, PrrC and, Type_I_REases.
@@ -78,14 +94,3 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
- - doi: 10.1006/jmbi.1995.0343
- - doi: 10.1186/1743-422X-7-360
-
----
-::
-
--
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