diff --git a/content/3.defense-systems/rosmerta.md b/content/3.defense-systems/rosmerta.md index db5e5087b8b04fa2d442a5765ee52ee61cc7b11f..b8aef238a85befddd493be551a50c932111aab59 100644 --- a/content/3.defense-systems/rosmerta.md +++ b/content/3.defense-systems/rosmerta.md @@ -24,11 +24,11 @@ The RosmerTA system was found to have antiviral activity and named after Gallo-R ## Molecular mechanisms -The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function :ref{doi=10.1016/j.chom.2022.09.017} and was later found to induce membrane depolarization :ref{doi=10.1073/pnas.2305393120}. +The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function :ref{doi=10.1016/j.chom.2022.09.017}. One toxin representative has been found to induce membrane depolarization :ref{doi=10.1073/pnas.2305393120}. ## Example of genomic structure -The RosmerTA is composed of 2 proteins: RmrT and RmrA. +The RosmerTA is composed of 2 proteins: RmrT and RmrA. The toxin can vary in sequence and structure. Here is an example found in the RefSeq database: @@ -88,3 +88,27 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> +<mermaid> +graph LR; + Ernits_2023[<a href='https://www.pnas.org/doi/10.1073/pnas.2305393120'>Ernits et al., 2023</a>] --> Origin_0 + Origin_0[Gordonia phage Kita +<a href='https://www.ncbi.nlm.nih.gov/protein/YP_009301394.1/'>YP_009301394.1</a>, <a href='https://www.ncbi.nlm.nih.gov/protein/YP_009301394.1'>YP_009301394.1</a>] --> Expressed_0[Escherichia coli] + Expressed_0[Escherichia coli] ----> Bas54 and Bas59 + subgraph Title1[Reference] + Ernits_2023 +end + subgraph Title2[System origin] + Origin_0 +end + subgraph Title3[Expression species] + Expressed_0 +end + subgraph Title4[Phage infected] + Bas54 + Bas59 +end + style Title1 fill:none,stroke:none,stroke-width:none + style Title2 fill:none,stroke:none,stroke-width:none + style Title3 fill:none,stroke:none,stroke-width:none + style Title4 fill:none,stroke:none,stroke-width:none +</mermaid>