diff --git a/content/2.defense-systems/1.PARIS.md b/content/2.defense-systems/1.PARIS.md index 449053c8cebb3411674e40281f69faf1b1f0e690..42b9716c714353da69f921f1c914a77242e092c1 100644 --- a/content/2.defense-systems/1.PARIS.md +++ b/content/2.defense-systems/1.PARIS.md @@ -5,6 +5,8 @@ toc: true # PARIS system + +test PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1). This system relies on an unknown [Abortive infection](/general_concepts/Abi) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3). @@ -73,4 +75,4 @@ items: - 10.1093/nar/gkaa290 - 10.1016/0022-2836(75)90083-2 --- -:: \ No newline at end of file +::