From 16b0287c319bc16e29edfe3ae942abcb14b2e533 Mon Sep 17 00:00:00 2001
From: rplanel-github <rplanel@gmail.com>
Date: Wed, 10 May 2023 14:51:19 +0200
Subject: [PATCH] Update 1.PARIS.md
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# PARIS system
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+test
PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1).
This system relies on an unknown [Abortive infection](/general_concepts/Abi) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3).
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- 10.1093/nar/gkaa290
- 10.1016/0022-2836(75)90083-2
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