diff --git a/content/3.defense-systems/drt.md b/content/3.defense-systems/drt.md index 748644c8741c94fda465adcca6f8401fd7c54cb1..f8d11e8430ad2c260e8f49d61ff921dc8c1c3421 100644 --- a/content/3.defense-systems/drt.md +++ b/content/3.defense-systems/drt.md @@ -10,9 +10,37 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF00078 +contributors: + - Helena Shomar + - Marie Guillaume +relevantAbstracts: + - doi: 10.1093/nar/gkac467 + - doi: 10.1126/science.aba0372 --- # DRT + +## Description +DRT stands for Defense-associated Reverse Transcriptases. +DRTs are a widespread and highly diverse family of defense systems, characterized by reverse transcriptase (RTs) components with antiphage properties. These RTs belong to the so-called group of unknown RTs (UG) and are closely related to the Abortive Infection system (Abi) RTs. + +DRT systems were experimentally validated in _Escherichia coli_ and demonstrated to be effective against an array of diverse phages. +So far, DRTs have been classified in 9 different types. Essential components of each DRT type are: +- DRT Type 1: UG1 (RT-nitrilaseTM domains) +- DRT Type 2: UG2 (RT domain) +- DRT Type 3: UG3 (RT domain), UG8 (RT domain) and ncRNA +- DRT Type 4: UG15 (RT-alphaRep domains) +- DRT Type 5: UG16 (RT domain) +- DRT Type 6: UG12 (RT-alphaRep domains) +- DRT Type 7: UG10 (PrimS-RT-alphaRep domains) +- DRT Type 8: UG7 (RT-alphaRep-PDDExK domains) +- DRT Type 9: UG28 (RT-alphaRep domains) and ncRNA + + +## Molecular mechanism +To our knowledge, the molecular mechanism is unknown. +Similarly, for the other systems of this family, the molecular mechanism remain unknown. + ## Example of genomic structure The DRT system have been describe in a total of 9 subsystems. @@ -267,14 +295,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts -::relevant-abstracts ---- -items: - - doi: 10.1093/nar/gkac467 - - doi: 10.1126/science.aba0372 - ---- -::