diff --git a/content/3.defense-systems/eleos.md b/content/3.defense-systems/eleos.md index 619bd3f24fc418460471268c5c2138015f01b664..88b2057cd86ecd0729fbe3fd3c710e5c1b424dd4 100644 --- a/content/3.defense-systems/eleos.md +++ b/content/3.defense-systems/eleos.md @@ -15,17 +15,20 @@ contributors: relevantAbstracts: - doi: 10.1016/j.chom.2022.09.017 - doi: 10.1101/2022.12.12.520048 - --- # Eleos + ## Description -The Eleos (for the greek goddess of mercy) system was previously described as the Dynamins-like system in :ref{doi=10.1016/j.chom.2022.09.017}. It is formed by the LeoA and LeoBC proteins. LeoBC has been found to be analogous to GIMAPs (GTPases immunity-associated proteins), that are interferon inducible :ref{doi=10.1101/2022.12.12.520048}. LeoA in *E. coli* ETEC H10407 localises to the periplasm and has been suggested to potientiate bacterial virulence. Its crystal structure has been solved :ref{doi=10.1371/journal.pone.0107211}. Eleos from *Bacillus vietnamensis* NBRC 101237 has been found to protect against jumbo-phages in *Bacillus subtilis* :ref{doi=10.1016/j.chom.2022.09.017}. + +\The Eleos (for the greek goddess of mercy) system was previously described as the Dynamins-like system in :ref{doi=10.1016/j.chom.2022.09.017}. It is formed by the LeoA and LeoBC proteins. LeoBC has been found to be analogous to GIMAPs (GTPases immunity-associated proteins), that are interferon inducible :ref{doi=10.1101/2022.12.12.520048}. LeoA in *E. coli* ETEC H10407 localises to the periplasm and has been suggested to potientiate bacterial virulence. Its crystal structure has been solved :ref{doi=10.1371/journal.pone.0107211}. Eleos from *Bacillus vietnamensis* NBRC 101237 has been found to protect against jumbo-phages in *Bacillus subtilis* :ref{doi=10.1016/j.chom.2022.09.017}. ## Molecular mechanism + As far as we are aware, the molecular mechanism is unknown. ## Example of genomic structure + The Eleos system is composed of 2 proteins: LeoA and, LeoBC. Sometimes, the system is in three genes: LeoA, LeoB and LeoC, or one gene LeoABC. Here is an example found in the RefSeq database: @@ -87,6 +90,3 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> - -:: -