diff --git a/content/3.defense-systems/shosta.md b/content/3.defense-systems/shosta.md index 9ad8cab412ed6b9eb855bb917ce0d723c18ae646..934c4230cbcdece5057a080b56fc7642bb6acbde 100644 --- a/content/3.defense-systems/shosta.md +++ b/content/3.defense-systems/shosta.md @@ -10,9 +10,23 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF02481 +relevantAbstracts: + - doi: 10.1016/j.chom.2022.09.017 + - doi: 10.1016/j.chom.2022.02.018 + - doi: 10.1101/gr.133850.111 --- # ShosTA + +## Description + +ShosTA system was first described as a Toxin/Antitoxin system in 2012 :ref{doi=10.1101/gr.133850.111} without demonstration of antiphage activity. In 2022, a paper described the same system as "DprA + PRTase" inside P2 like prophages and prooves its antiphage activity. Finally, the antiphage activity was also prooved in another study with the original name ShosTA :ref{doi=10.1016/j.chom.2022.09.017}. + +This system is composed of two protein: ShosT and ShosA encoding for Hydrolase/PRTase and DprA (nucleotid binding) respectively. + +## Molecular mechanism +The ShosTA system is a toxin (ShosT) antitoxin (ShosA) system. The domains of ShosT (Hydrolase and PRTase) allows us to hypothesize a toxicity linked to host protein degradation. + ## Example of genomic structure The ShosTA is composed of 2 proteins: ShosA and ShosT. @@ -88,15 +102,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.09.017 - - doi: 10.1016/j.chom.2022.09.017 - - doi: 10.1101/gr.133850.111 - ---- -::