From 375c5e6d9968d7efcf7e155aebf10b8b3d8244d8 Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@pasteur.fr>
Date: Tue, 23 Jan 2024 13:35:32 +0100
Subject: [PATCH] add information RloC
---
content/3.defense-systems/rloc.md | 17 +++++++++++++++--
1 file changed, 15 insertions(+), 2 deletions(-)
diff --git a/content/3.defense-systems/rloc.md b/content/3.defense-systems/rloc.md
index 63a94b10..4cf6cacb 100644
--- a/content/3.defense-systems/rloc.md
+++ b/content/3.defense-systems/rloc.md
@@ -10,12 +10,25 @@ tableColumns:
Activator: Unknown
Effector: Nucleic acid degrading
PFAM: PF13166
+contributors:
+ - Aude Bernheim
+ - Florian Tesson
relevantAbstracts:
- - doi: 10.1111/j.1365-2958.2008.06387.x
- - doi: 10.1111/mmi.13074
+ - doi: 10.1111/j.1365-2958.2008.06387.x
---
# RloC
+
+## Description
+
+RloC is a distant homolog of the tRNALys anticodon nuclease (ACNase) [PrrC](/defense-systems/prrc). RloC shares the ABC ATPase motifs and catalytic ACNase triad with PrrC, but it possesses a unique zinc-hook/coiled-coil insert. This distinctive feature results in its ATPase domain bearing similarity to Rad50 and other DNA repair proteins.Contrary to PrrC RloC is rarely linked to a type I R-M system. RloC activity was not directly demonstrated on phages but hypothesized through its similar features to PrrC :ref{doi=10.1111/j.1365-2958.2008.06387.x}.
+
+This system was not experimentally validated but is still considered as a defense system because of its homology with [PrrC](/defense-systems/prrc) and its abundance in [defense islands](/general-concepts/defense-islands). Of the RloC system detected by DefenseFinder around 40% are close to at least one known defense system (20 proteins on each side).
+
+## Molecular Mechanism
+
+RloC was shown to function by tRNA cleavage (wobble nucleotide-excising and Zn++-responsive tRNase) :ref{doi=10.1006/jmbi.1995.0343}. However, such activity was not directly shown on a phage
+ Zinc hook seems to regulate the nuclease function.
## Example of genomic structure
The RloC is composed of 1 protein: RloC.
--
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