diff --git a/content/3.defense-systems/mokosh.md b/content/3.defense-systems/mokosh.md index 5373c9a07deedb702db438182fc136e5cfdf5445..5509c215d320be6c19aac18323da8dfa1888fce7 100644 --- a/content/3.defense-systems/mokosh.md +++ b/content/3.defense-systems/mokosh.md @@ -10,9 +10,21 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF00069, PF07714, PF08378, PF13086, PF13087, PF13091, PF13245, PF13604 +contributors: + - Marian Dominguez-Mirazo +relevantAbstract: + - doi: 10.1016/j.chom.2022.09.017 + - doi: 10.1101/2022.12.12.520048 --- # Mokosh + +## Description +The Mokosh system was discovered in *E. coli* by examining clusters of genes enrinched in defense islands :ref{doi=10.1016/j.chom.2022.09.017}. It contains genes with an RNA helicase domain and a predicted phospholipase D domain (PLD) nuclease domain. Mutations in the ATP-binding domain of the helicase, and in the active site of the PLD nuclease disrupt phage defense. The system is divided in two types. Mokosh type I has two genes, one gene containing the RNA helicase domain and an additional serine-threonine kinase domain (STK), and one gene containing the PLD nuclease. Type II Mokosh is formed of a single gene containing both the helicase and nuclease domains. Recent efforts have shown homology between the Mokosh system and human proteins involved in the piRNA pathway, a defense mechanism of animal germlines that prevents expression of transposable elements :ref{doi=10.1101/2022.12.12.520048}. The system gets its name from the goddess protector of women's destiny in Slavic mythology :ref{doi=10.1016/j.chom.2022.09.017}. + +## Molecular mechanisms +As far as we are aware, the molecular mechanism is unknown. + ## Example of genomic structure The Mokosh system have been describe in a total of 2 subsystems. @@ -126,13 +138,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.09.017 - ---- -::