From 3f9d3f650137c68c757e0419322e508207540c29 Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Mon, 22 Jan 2024 09:27:33 +0100
Subject: [PATCH] Update abid.md
---
content/3.defense-systems/abid.md | 17 ++++++++++++++++-
1 file changed, 16 insertions(+), 1 deletion(-)
diff --git a/content/3.defense-systems/abid.md b/content/3.defense-systems/abid.md
index 6b581d30..2844485c 100644
--- a/content/3.defense-systems/abid.md
+++ b/content/3.defense-systems/abid.md
@@ -10,13 +10,29 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF07751
+contributors:
+ - Marian Dominguez-Mirazo
+ - Florian Tesson
relevantAbstracts:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
+ - doi: 10.1128/aem.61.5.2023-2026.1995
---
# AbiD
+## Description
+
+AbiD is a single gene system system discovered in May 1995 in the plasmid pBF61 of *Lactococcus lactis* :ref{doi=10.1128/aem.61.5.2023-2026.1995}. An homolog of AbiD, named AbiD1 was discovered in July 1995 :ref{doi=10.1128/jb.177.13.3818-3823.1995}.
+
+AbiD is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiR is classified as a possible abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
+
+This antiphage defense system is very close to AbiD1 and AbiF :ref{doi=10.1128/aem.61.12.4321-4328.1995} and is categorized as the same system. Furthermore, AbiD is also detected as the [Abi2](/defense-systems/abi2) system.
+
+### Molecular mechanism
+
+For AbiD1 :ref{doi=10.1128/jb.177.13.3824-3829.1995} ([AAA79209](https://www.ncbi.nlm.nih.gov/protein/AAA79209)), the expression of the protein is toxic to the bacteria and is therefore highly regulated. Expression of the protein is triggered by the orf1 of phage bIL66 which results in inhibition of the phage RuvC-like endonuclease activity and stops phage multiplication.
+
## Example of genomic structure
The AbiD is composed of 1 protein: AbiD.
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style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
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