diff --git a/content/2.defense-systems/avast.md b/content/2.defense-systems/avs.md similarity index 70% rename from content/2.defense-systems/avast.md rename to content/2.defense-systems/avs.md index a0a204cd6228e8dffdacc7a636f6ff3d2454f3cc..bc7e2b04eb8793b847a9e2138eede95ac03de1fd 100644 --- a/content/2.defense-systems/avast.md +++ b/content/2.defense-systems/avs.md @@ -1,5 +1,5 @@ --- -title: AVAST +title: Avs tableColumns: article: doi: 10.1126/science.aba0372 @@ -11,54 +11,54 @@ tableColumns: --- -# AVAST -# AVAST +# Avs +# Avs ## Description -AVAST (antiviral ATPases/NTPases of the STAND superfamily) is a group of anti-phage defense systems, active against some dsDNA phages. +Avs (antiviral ATPases/NTPases of the STAND superfamily) is a group of anti-phage defense systems, active against some dsDNA phages. -AVAST systems are composed of NTPases of the STAND (signal transduction ATPases with numerous associated domains) superfamily (1).  STAND-NTPases typically contain a C-terminal helical sensor domain that activates the N-terminal effector domain upon target recognition (1). +Avs systems are composed of NTPases of the STAND (signal transduction ATPases with numerous associated domains) superfamily (1).  STAND-NTPases typically contain a C-terminal helical sensor domain that activates the N-terminal effector domain upon target recognition (1). -In eukaryotes, STAND-NTPases are associated with programmed cell death, therefore Gao and colleagues hypothesized that AVAST might function through an Abortive infection mechanism. +In eukaryotes, STAND-NTPases are associated with programmed cell death, therefore Gao and colleagues hypothesized that Avs might function through an Abortive infection mechanism. ## Example of genomic structure -The AVAST system have been describe in a total of 5 subsystems. +The Avs system have been describe in a total of 5 subsystems. Here is some example found in the RefSeq database: -{max-width=750px} +{max-width=750px} -AVAST_I subsystem in the genome of *Vibrio sp.* (GCF_905175355.1) is composed of 3 proteins: Avs1A (WP_208445041.1), Avs1B (WP_208445042.1)and, Avs1C (WP_108173272.1). +Avs_I subsystem in the genome of *Vibrio sp.* (GCF_905175355.1) is composed of 3 proteins: Avs1A (WP_208445041.1), Avs1B (WP_208445042.1)and, Avs1C (WP_108173272.1). -{max-width=750px} +{max-width=750px} -AVAST_II subsystem in the genome of *Escherichia coli* (GCF_018884505.1) is composed of 1 protein: Avs2A (WP_032199984.1). +Avs_II subsystem in the genome of *Escherichia coli* (GCF_018884505.1) is composed of 1 protein: Avs2A (WP_032199984.1). -{max-width=750px} +{max-width=750px} -AVAST_III subsystem in the genome of *Enterobacter cancerogenus* (GCF_002850575.1) is composed of 2 proteins: Avs3B (WP_199559884.1)and, Avs3A (WP_101737373.1). +Avs_III subsystem in the genome of *Enterobacter cancerogenus* (GCF_002850575.1) is composed of 2 proteins: Avs3B (WP_199559884.1)and, Avs3A (WP_101737373.1). -{max-width=750px} +{max-width=750px} -AVAST_IV subsystem in the genome of *Escherichia coli* (GCF_016903595.1) is composed of 1 protein: Avs4A (WP_000240574.1). +Avs_IV subsystem in the genome of *Escherichia coli* (GCF_016903595.1) is composed of 1 protein: Avs4A (WP_000240574.1). -{max-width=750px} +{max-width=750px} -AVAST_V subsystem in the genome of *Leclercia adecarboxylata* (GCF_006171285.1) is composed of 1 protein: Avs5A (WP_139565349.1). +Avs_V subsystem in the genome of *Leclercia adecarboxylata* (GCF_006171285.1) is composed of 1 protein: Avs5A (WP_139565349.1). ## Distribution of the system among prokaryotes -The AVAST system is present in a total of 363 different species. +The Avs system is present in a total of 363 different species. Among the 22k complete genomes of RefSeq, this system is present in 1046 genomes (4.6 %). -{max-width=750px} +{max-width=750px} -*Proportion of genome encoding the AVAST system for the 14 phyla with more than 50 genomes in the RefSeq database.* *Pie chart of the repartition of all the subsystems found in the RefSeq database.* +*Proportion of genome encoding the Avs system for the 14 phyla with more than 50 genomes in the RefSeq database.* *Pie chart of the repartition of all the subsystems found in the RefSeq database.* ## Experimental validation -AVAST systems were experimentally validated using: +Avs systems were experimentally validated using: Subsystem SIR2-STAND with a system from *Escherichia fergusonii's PICI (EfCIRHB19-C05)* in *Escherichia coli* has an anti-phage effect against T4, Lambda, HK97, HK544, HK578, T7 (Fillol-Salom et al., 2022) diff --git a/public/avast/AVAST_I.svg b/public/avs/Avs_I.svg similarity index 100% rename from public/avast/AVAST_I.svg rename to public/avs/Avs_I.svg diff --git a/public/avast/AVAST_II.svg b/public/avs/Avs_II.svg similarity index 100% rename from public/avast/AVAST_II.svg rename to public/avs/Avs_II.svg diff --git a/public/avast/AVAST_III.svg b/public/avs/Avs_III.svg similarity index 100% rename from public/avast/AVAST_III.svg rename to public/avs/Avs_III.svg diff --git a/public/avast/AVAST_IV.svg b/public/avs/Avs_IV.svg similarity index 100% rename from public/avast/AVAST_IV.svg rename to public/avs/Avs_IV.svg diff --git a/public/avast/AVAST_V.svg b/public/avs/Avs_V.svg similarity index 100% rename from public/avast/AVAST_V.svg rename to public/avs/Avs_V.svg diff --git a/public/avast/Distribution_AVAST.svg b/public/avs/Distribution_Avs.svg similarity index 100% rename from public/avast/Distribution_AVAST.svg rename to public/avs/Distribution_Avs.svg