From 4a0b6e3e95daf12fbe3b1f748fe4c662f18ad9fd Mon Sep 17 00:00:00 2001
From: mdomingu <marian.dominguez-mirazo@pasteur.fr>
Date: Fri, 15 Dec 2023 17:02:21 +0100
Subject: [PATCH] Update mokosh.md
---
content/3.defense-systems/mokosh.md | 20 ++++++++++++--------
1 file changed, 12 insertions(+), 8 deletions(-)
diff --git a/content/3.defense-systems/mokosh.md b/content/3.defense-systems/mokosh.md
index 5373c9a0..5509c215 100644
--- a/content/3.defense-systems/mokosh.md
+++ b/content/3.defense-systems/mokosh.md
@@ -10,9 +10,21 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF00069, PF07714, PF08378, PF13086, PF13087, PF13091, PF13245, PF13604
+contributors:
+ - Marian Dominguez-Mirazo
+relevantAbstract:
+ - doi: 10.1016/j.chom.2022.09.017
+ - doi: 10.1101/2022.12.12.520048
---
# Mokosh
+
+## Description
+The Mokosh system was discovered in *E. coli* by examining clusters of genes enrinched in defense islands :ref{doi=10.1016/j.chom.2022.09.017}. It contains genes with an RNA helicase domain and a predicted phospholipase D domain (PLD) nuclease domain. Mutations in the ATP-binding domain of the helicase, and in the active site of the PLD nuclease disrupt phage defense. The system is divided in two types. Mokosh type I has two genes, one gene containing the RNA helicase domain and an additional serine-threonine kinase domain (STK), and one gene containing the PLD nuclease. Type II Mokosh is formed of a single gene containing both the helicase and nuclease domains. Recent efforts have shown homology between the Mokosh system and human proteins involved in the piRNA pathway, a defense mechanism of animal germlines that prevents expression of transposable elements :ref{doi=10.1101/2022.12.12.520048}. The system gets its name from the goddess protector of women's destiny in Slavic mythology :ref{doi=10.1016/j.chom.2022.09.017}.
+
+## Molecular mechanisms
+As far as we are aware, the molecular mechanism is unknown.
+
## Example of genomic structure
The Mokosh system have been describe in a total of 2 subsystems.
@@ -126,13 +138,5 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-::relevant-abstracts
----
-items:
- - doi: 10.1016/j.chom.2022.09.017
-
----
-::
--
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