diff --git a/content/3.defense-systems/rst_rt-nitrilase-tm.md b/content/3.defense-systems/rst_rt-nitrilase-tm.md index 55eaa9ea9bfbcd8b6ec86203a759cc6f7d8c4249..e0506ada301529ec22e756312cf8ac07d226f5d9 100644 --- a/content/3.defense-systems/rst_rt-nitrilase-tm.md +++ b/content/3.defense-systems/rst_rt-nitrilase-tm.md @@ -20,13 +20,14 @@ relevantAbstracts: # RT-nitrilase-Tm ## Description -RT-nitrilase-Tm (also named UG5-large) is a two genes defense system. It was discovered from P4-like satellites in *E. coli* genomes :ref{doi=10.1016/j.chom.2022.02.01} :ref{doi=10.1093/nar/gkac467}. Its antiphage activity was shown in *E. coli* against phage AL505_P2 (Myoviridae). +RT-nitrilase-Tm (also named UG5-large) is a two-gene defense system. It was discovered from P4-like satellites in *E. coli* genomes :ref{doi=10.1016/j.chom.2022.02.018} :ref{doi=10.1093/nar/gkac467}. Its antiphage activity was shown in *E. coli* against phage AL505_P2 (Myoviridae). The first protein is a reverse transcriptase (RT) fussed with C-N hydrolase domain (nitrilase) ; the second protein is transmembrane protein :ref{doi=10.1093/nar/gkac467}. -The presence of a RT protein allows to draw a parallel between this system and the [DRT defense system](/defense-systems/drt). +The presence of an RT protein allows to draw a parallel between this system and the [DRT defense system](/defense-systems/drt). ## Molecular mechanism + As far as we are aware, the molecular mechanism is unknown. ## Example of genomic structure