diff --git a/content/3.defense-systems/jukab.md b/content/3.defense-systems/jukab.md index 61f8bb4ebdcac718c53573ed7508cd47fb054ae9..1f6778e9540bca7a3caf981ae832cfdcdb04be71 100644 --- a/content/3.defense-systems/jukab.md +++ b/content/3.defense-systems/jukab.md @@ -13,7 +13,16 @@ relevantAbstracts: # JukAB -## To do +## Description +JukAB was shown to be active against nucleus-like forming Jumbo phages :ref{doi=10.1038/s41586-022-05013-4} in *Pseudomonas aeruginosa* :ref{doi=10.1101/2022.09.17.508391}. This system was named JukAB for **Ju**mbo phage **K*iller. + +JukAB is composed of two protein JukA and JukB. JukA encode for the DUF3944 domain present in other potential defense system according to :ref{doi=10.1101/2022.09.17.508391}. + +## Molecular mechanism + +JukAB is acting at the early stage of PhiKZ infection before the phage forms its nucleus. + +Using fluorescence microscopy, the authors showed that JukA is acting as a sensor of the phage infection using PhiKZ ejection factors :ref{doi=10.1101/2022.09.17.508391}. After the detection of the infection by JukA, JukB is recruted and the phage ## Example of genomic structure