diff --git a/content/3.defense-systems/abiq.md b/content/3.defense-systems/abiq.md index b9bec1ad48e4788b2e57cfe91d8b3fc945f14a62..712cf0f3a528829fe4a06f8d10d3619ff65554d2 100644 --- a/content/3.defense-systems/abiq.md +++ b/content/3.defense-systems/abiq.md @@ -10,9 +10,33 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF13958 +contributors: + - Florian Tesson +relevantAbstracts: + - doi: 10.1023/A:1002027321171 + - doi: 10.1016/j.mib.2005.06.006 + - doi: 10.1128/AEM.64.12.4748-4756.1998 + - doi: 10.1111/mmi.12129 --- # AbiQ + +## Description + +AbiQ was discovered in 1998 on *Lactococcus lactis* plasmid :ref{doi=10.1128/AEM.64.12.4748-4756.1998}. + +AbiQ is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiQ is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}. + +AbiQ is composed of a single protein AbiQ and a RNA anti toxin (antiQ) :ref{doi=10.1111/mmi.12129}. + +## Molecular mechanism + +AbiQ act as an anti-toxin type III. AbiQ is a RNAase that will bind its antitoxin antiQ :ref{doi=10.1111/mmi.12129}. + +The AbiQ is constitutively expressed and bind to its antiQ RNA resulting in a inactivated AbiQ. +To get activated, AbiQ need the concentration of antiQ to decrease. +However, during phage infection, the expression of the antiQ is constant and the author do not know how the AbiQ is activated :ref{doi=10.1111/mmi.12129}. + ## Example of genomic structure The AbiQ is composed of 1 protein: AbiQ. @@ -35,6 +59,17 @@ Proportion of genome encoding the AbiQ system for the 14 phyla with more than 50 ## Structure +### Experimentaly determined structure + +From :ref{doi=10.1111/mmi.12129} in *Lactococcus lactis*: + +::molstar-pdbe-plugin +--- +height: 700 +dataUrl: /abiq/4glk_LlAbiQ_1mer.cif +--- +:: + ### AbiQ