From 60af0d79baeb639b42afc1902962f089efaa72bd Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Tue, 9 Jan 2024 17:30:28 +0100
Subject: [PATCH] Update abiq.md
---
content/3.defense-systems/abiq.md | 35 +++++++++++++++++++++++++++++++
1 file changed, 35 insertions(+)
diff --git a/content/3.defense-systems/abiq.md b/content/3.defense-systems/abiq.md
index b9bec1ad..712cf0f3 100644
--- a/content/3.defense-systems/abiq.md
+++ b/content/3.defense-systems/abiq.md
@@ -10,9 +10,33 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF13958
+contributors:
+ - Florian Tesson
+relevantAbstracts:
+ - doi: 10.1023/A:1002027321171
+ - doi: 10.1016/j.mib.2005.06.006
+ - doi: 10.1128/AEM.64.12.4748-4756.1998
+ - doi: 10.1111/mmi.12129
---
# AbiQ
+
+## Description
+
+AbiQ was discovered in 1998 on *Lactococcus lactis* plasmid :ref{doi=10.1128/AEM.64.12.4748-4756.1998}.
+
+AbiQ is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiQ is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
+
+AbiQ is composed of a single protein AbiQ and a RNA anti toxin (antiQ) :ref{doi=10.1111/mmi.12129}.
+
+## Molecular mechanism
+
+AbiQ act as an anti-toxin type III. AbiQ is a RNAase that will bind its antitoxin antiQ :ref{doi=10.1111/mmi.12129}.
+
+The AbiQ is constitutively expressed and bind to its antiQ RNA resulting in a inactivated AbiQ.
+To get activated, AbiQ need the concentration of antiQ to decrease.
+However, during phage infection, the expression of the antiQ is constant and the author do not know how the AbiQ is activated :ref{doi=10.1111/mmi.12129}.
+
## Example of genomic structure
The AbiQ is composed of 1 protein: AbiQ.
@@ -35,6 +59,17 @@ Proportion of genome encoding the AbiQ system for the 14 phyla with more than 50
## Structure
+### Experimentaly determined structure
+
+From :ref{doi=10.1111/mmi.12129} in *Lactococcus lactis*:
+
+::molstar-pdbe-plugin
+---
+height: 700
+dataUrl: /abiq/4glk_LlAbiQ_1mer.cif
+---
+::
+
### AbiQ
--
GitLab