diff --git a/content/3.defense-systems/rst_rt-nitrilase-tm.md b/content/3.defense-systems/rst_rt-nitrilase-tm.md index 8668f08920e7174a41140a1d0de485022c3b7847..55eaa9ea9bfbcd8b6ec86203a759cc6f7d8c4249 100644 --- a/content/3.defense-systems/rst_rt-nitrilase-tm.md +++ b/content/3.defense-systems/rst_rt-nitrilase-tm.md @@ -10,11 +10,25 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF00078 +contributors: + - Hugo Vaysset relevantAbstracts: - doi: 10.1016/j.chom.2022.02.018 + - doi: 10.1093/nar/gkac467 --- -# Rst_RT-nitrilase-Tm +# RT-nitrilase-Tm + +## Description +RT-nitrilase-Tm (also named UG5-large) is a two genes defense system. It was discovered from P4-like satellites in *E. coli* genomes :ref{doi=10.1016/j.chom.2022.02.01} :ref{doi=10.1093/nar/gkac467}. Its antiphage activity was shown in *E. coli* against phage AL505_P2 (Myoviridae). + +The first protein is a reverse transcriptase (RT) fussed with C-N hydrolase domain (nitrilase) ; the second protein is transmembrane protein :ref{doi=10.1093/nar/gkac467}. + +The presence of a RT protein allows to draw a parallel between this system and the [DRT defense system](/defense-systems/drt). + +## Molecular mechanism +As far as we are aware, the molecular mechanism is unknown. + ## Example of genomic structure The Rst_RT-nitrilase-Tm is composed of 2 proteins: RT and RT-Tm.