From 60b9dd10abaf39c98f60ab11395b8bad3d61d3f0 Mon Sep 17 00:00:00 2001
From: hvaysset <hugo.vaysset@cri-paris.org>
Date: Tue, 16 Jan 2024 13:26:54 +0100
Subject: [PATCH] Rst rt nitrilase tm
---
content/3.defense-systems/rst_rt-nitrilase-tm.md | 16 +++++++++++++++-
1 file changed, 15 insertions(+), 1 deletion(-)
diff --git a/content/3.defense-systems/rst_rt-nitrilase-tm.md b/content/3.defense-systems/rst_rt-nitrilase-tm.md
index 8668f089..55eaa9ea 100644
--- a/content/3.defense-systems/rst_rt-nitrilase-tm.md
+++ b/content/3.defense-systems/rst_rt-nitrilase-tm.md
@@ -10,11 +10,25 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF00078
+contributors:
+ - Hugo Vaysset
relevantAbstracts:
- doi: 10.1016/j.chom.2022.02.018
+ - doi: 10.1093/nar/gkac467
---
-# Rst_RT-nitrilase-Tm
+# RT-nitrilase-Tm
+
+## Description
+RT-nitrilase-Tm (also named UG5-large) is a two genes defense system. It was discovered from P4-like satellites in *E. coli* genomes :ref{doi=10.1016/j.chom.2022.02.01} :ref{doi=10.1093/nar/gkac467}. Its antiphage activity was shown in *E. coli* against phage AL505_P2 (Myoviridae).
+
+The first protein is a reverse transcriptase (RT) fussed with C-N hydrolase domain (nitrilase) ; the second protein is transmembrane protein :ref{doi=10.1093/nar/gkac467}.
+
+The presence of a RT protein allows to draw a parallel between this system and the [DRT defense system](/defense-systems/drt).
+
+## Molecular mechanism
+As far as we are aware, the molecular mechanism is unknown.
+
## Example of genomic structure
The Rst_RT-nitrilase-Tm is composed of 2 proteins: RT and RT-Tm.
--
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