From 630c83c06044dd44e1e935abde054763aba5fa0c Mon Sep 17 00:00:00 2001
From: Jean CURY <jean.cury@pasteur.fr>
Date: Tue, 19 Dec 2023 17:14:24 +0100
Subject: [PATCH] Update 2.defense-islands.md
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- Ernest Mordret
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+# Defense Islands
**Defense islands** are regions of prokaryotic genomes enriched in defense systems. Their existence first described in Makarova *et al.*:ref{doi=10.1128/JB.05535-11}, who observed that genes encoding defense systems (mainly Restriction Modification enzymes, Toxin-Antitoxin systems, but notably not CRISPR) tended to cluster preferentially on specific portions of bacterial genomes. They postulated that unknown genes commonly found associated to these regions would likely have a defensive role themselves, and confirmed bioinformatically that many of them were indeed diverged versions of classical defense systems. Other systems of genes commonly found in defense islands were later isolated and heterologously expressed to experimentally confirm to have a defensive role (BREX, DISARM). Doron *et al.*:ref{10.1126/science.aar4120}, later followed by Millmann *et al.*:ref{https://doi.org/10.1016/j.chom.2022.09.017}, used the colocalization of genes in defense islands to generate many candidate systems and test them experimentally in high throughput screens, leading to the discovery of a large number of new defense systems.
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