diff --git a/content/3.defense-systems/fs_hsdr_like.md b/content/3.defense-systems/fs_hsdr_like.md index 4f07aeee7b3cd567ddfebdff0eba4f190482a0d8..d6e4bcac71da62868ea64ef5560aadcbfcf3e120 100644 --- a/content/3.defense-systems/fs_hsdr_like.md +++ b/content/3.defense-systems/fs_hsdr_like.md @@ -12,7 +12,17 @@ relevantAbstracts: # FS_HsdR_like -## To do +## Description + +FS_HsdR_like or HsdR_like was discovered in 2022 :ref{doi=10.1016/j.cell.2022.07.014} inside the PICI KpCIC51 in *Klebsiella pneumoniae*. + +The HsdR_like system is also effective for blocking conjugation. + +The HsdR_like system is composed of tree genes. A first protein encoding a DUF6731 domain and named after it. An hypothetical protein and the HsdR protein with an N terminal HEPN domain and C terminal Zn finger domain. + +## Molecular mechanism + +As far as we are aware, the molecular mechanism is unknown. ## Example of genomic structure @@ -66,7 +76,7 @@ dataUrls: graph LR; Fillol-Salom_2022[<a href='https://doi.org/10.1016/j.cell.2022.07.014'>Fillol-Salom et al., 2022</a>] --> Origin_0 Origin_0[Klebsiella pneumoniae -<a href='https://ncbi.nlm.nih.gov/protein/QFH39805.1'>QFH39805.1</a>, <a href='https://ncbi.nlm.nih.gov/protein/RXS01985.1'>RXS01985.1</a>] --> Expressed_0[Escherichia coli] +<a href='https://ncbi.nlm.nih.gov/protein/QFH39804.1'>QFH39804.1</a>, <a href='https://ncbi.nlm.nih.gov/protein/QFH39805.1'>QFH39805.1, <a href='https://ncbi.nlm.nih.gov/protein/QFH39806.1'>QFH39806.1</a>] --> Expressed_0[Escherichia coli] Expressed_0[Escherichia coli] ----> T5 & Lambda & HK97 & HK544 & HK544 & HK578 & T7 Fillol-Salom_2022[<a href='https://doi.org/10.1016/j.cell.2022.07.014'>Fillol-Salom et al., 2022</a>] --> Origin_0 Origin_0[Klebsiella pneumoniae