diff --git a/content/3.defense-systems/olokun.md b/content/3.defense-systems/olokun.md index d953143009ce4ebf122b98b884b27b15af5489e8..3ec671eea84d6cfc3aa45db4527e3bef4fee6959 100644 --- a/content/3.defense-systems/olokun.md +++ b/content/3.defense-systems/olokun.md @@ -4,7 +4,7 @@ layout: article tableColumns: article: doi: 10.1016/j.chom.2022.09.017 - abstract: + abstract: | Bacterial anti-phage systems are frequently clustered in microbial genomes, forming defense islands. This property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but the full arsenal of anti-phage mechanisms remains unknown. We report the discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments. We identified multiple systems with domains involved in eukaryotic antiviral immunity, including those homologous to the ubiquitin-like ISG15 protein, dynamin-like domains, and SEFIR domains, and show their participation in bacterial defenses. Additional systems include domains predicted to manipulate DNA and RNA molecules, alongside toxin-antitoxin systems shown here to function in anti-phage defense. These systems are widely distributed in microbial genomes, and in some bacteria, they form a considerable fraction of the immune arsenal. Our data substantially expand the inventory of defense systems utilized by bacteria to counteract phage infection. Sensor: Unknown Activator: Unknown