diff --git a/content/3.defense-systems/paris.md b/content/3.defense-systems/paris.md index 4a08c649ca373a95771938e5412a9b5b153fe0db..d3badc5b2346d7959aea000e50f65e95afa9d0b8 100644 --- a/content/3.defense-systems/paris.md +++ b/content/3.defense-systems/paris.md @@ -9,13 +9,19 @@ tableColumns: Sensor: Sensing of phage protein Activator: Unknown Effector: Unknown +contributors: + - Lucas Paoli +relevantAbstracts: + - doi: 10.1016/j.chom.2022.02.018 --- # Paris ## Description -PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1). +PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1). + +## Molecular mechanisms This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3). @@ -145,13 +151,3 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.02.018 - - ---- -::