diff --git a/content/3.defense-systems/wadjet.md b/content/3.defense-systems/wadjet.md index 11b8ff0c8c853b66394bf78cd7ad58465c574dc1..7cc4ccf633ce020cae5e2c43f7b101a098cb00a7 100644 --- a/content/3.defense-systems/wadjet.md +++ b/content/3.defense-systems/wadjet.md @@ -32,8 +32,8 @@ This system is composed of 4 genes: JetA, JetB, JetC and JetD. JetA, JetB and Je The anti-plasmid activity of Wadjet was shown to be a DNA cleaving mechanism specific to close circular DNA :ref{doi=10.1098/rstb.2004.1606}. The JetABC complex will act as a sensor detecting the foreign DNA using topology sensing. -JetD protein is a homodimeric endonuclease that cleaves double stranded DNA. -JetD need to be in contact with the JetABC complex to be able to cleave DNA. +JetD protein is a homodimeric endonuclease that cleaves double-stranded DNA. +JetD needs to be in contact with the JetABC complex to be able to cleave DNA. The mechanism suggested by :ref{doi=10.1098/rstb.2004.1606} is that the complex will bind to the DNA and will extrude loops similarly to Muk and other SMC proteins :ref{doi=10.1126/science.abm4012,10.1126/science.abb0981} that will then be cleave by JetD. @@ -70,7 +70,7 @@ Proportion of genome encoding the Wadjet system for the 14 phyla with more than ## Structure -### Experimentaly determined structure +### Experimentally determined structure From :ref{doi=10.1098/rstb.2004.1606} in *Pseudomonas aeruginosa* PA14: