diff --git a/content/3.defense-systems/eleos.md b/content/3.defense-systems/eleos.md index fab1f736c6c4448ebc873bfb38fc6c71e9b69575..60836d57c049cb34d48fe6c53ed23324325269df 100644 --- a/content/3.defense-systems/eleos.md +++ b/content/3.defense-systems/eleos.md @@ -10,13 +10,28 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF00350, PF01926, PF18709 + +contributors: + - Alba Herrero del Valle +## Relevant abstracts + +::relevant-abstracts +--- +items: + - doi: 10.1016/j.chom.2022.09.017 + - doi: 10.1101/2022.12.12.520048 + +--- --- # Eleos -The Eleos system was previously described as the Dynamins-like system in (Millman et al, 2022). +## Description +The Eleos (for the greek goddess of mercy) system was previously described as the Dynamins-like system in by Millman et al. :ref{doi=10.1016/j.chom.2022.09.017}. It is formed by the LeoA and LeoBC proteins. LeoBC has been found to be analogous to GIMAPs (GTPases immunity-associated proteins), that are interferon inducible :ref{doi=10.1101/2022.12.12.520048}. LeoA in *E. coli* ETEC H10407 localises to the periplasm and has been suggested to potientiate bacterial virulence. Its crystal structure has been solved :ref{doi=10.1371/journal.pone.0107211}. Eleos from *Bacillus vietnamensis* NBRC 101237 has been found to protect against jumbo-phages in *Bacillus subtilis* :ref{doi=10.1016/j.chom.2022.09.017}. +## Molecular mechanism +As far as we are aware, the molecular mechanism is unknown. ## Example of genomic structure -The Eleos system is composed of 2 proteins: LeoA and, LeoBC. Sometimes, the systems is in three genes: LeoA, LeoB and LeoC. +The Eleos system is composed of 2 proteins: LeoA and, LeoBC. Sometimes, the system is in three genes: LeoA, LeoB and LeoC, or one gene LeoABC. Here is an example found in the RefSeq database: @@ -77,13 +92,6 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.09.017 ---- ::