diff --git a/content/3.defense-systems/abie.md b/content/3.defense-systems/abie.md index a78e824cffd3ce9866232d3855ac96b003144de2..dd327dda2c86083d2bd818e767f9cbfbe00b08f4 100644 --- a/content/3.defense-systems/abie.md +++ b/content/3.defense-systems/abie.md @@ -10,22 +10,31 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF08843, PF09407, PF09952, PF11459, PF13338, PF17194 +contributors: + - Florian Tesson relevantAbstracts: - doi: 10.1023/A:1002027321171 - doi: 10.1016/j.mib.2005.06.006 - doi: 10.1093/nar/gkt1419 + - doi: 10.1128/aem.61.12.4321-4328.1995 --- # AbiE -AbiE is a family of an anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity. -It is classified as an Abortive infection system. +## Description +AbiE was discovered in 1995 on a Lactococcal plasmid :ref{doi=10.1128/aem.61.12.4321-4328.1995} together with AbiF a homolog of [AbiD](/defense-systems/abid)](/defense-systems/abid). + +AbiE is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiE is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}. + +AbiE is composed of two proteins: AbiEi and AbiEii. AbiEii is annotated as a nucleotidyltransferase. ## Molecular mechanism -AbiE systems are encoded by two mandatory genes, abiEi and abiEii (1,2).  The latter encodes for AbiEii, a GTP-binding nucleotidyltransferase (NTase) which expression induce a reversible growth arrest.  On the other hand, abiEi encodes for a AbiEi a transcriptional autorepressor that  binds to the promoter of the abiE operon. +AbiE is a family of anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity :ref{doi=10.1093/nar/gkt1419}. + +AbiEii is a GTP-binding nucleotidyltransferase (NTase) whose expression induces a reversible growth arrest :ref{doi=10.1093/nar/gkt1419}. On the other hand, AbiEi is a transcriptional autorepressor that binds to the promoter of the abiE operon. +Based on these mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin systems, where the antitoxin and toxin are both proteins that do not directly interact with each other :ref{doi=10.1093/nar/gkt1419}. -Based on this mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin system, where the antitoxin and toxin are both proteins that do not directly interact with each other. ## Example of genomic structure