From 754381d82c4ee65da436efbb983ffe23d3355c86 Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Mon, 22 Jan 2024 17:38:07 +0100
Subject: [PATCH] add information on abie.md
---
content/3.defense-systems/abie.md | 17 +++++++++++++----
1 file changed, 13 insertions(+), 4 deletions(-)
diff --git a/content/3.defense-systems/abie.md b/content/3.defense-systems/abie.md
index a78e824c..dd327dda 100644
--- a/content/3.defense-systems/abie.md
+++ b/content/3.defense-systems/abie.md
@@ -10,22 +10,31 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF08843, PF09407, PF09952, PF11459, PF13338, PF17194
+contributors:
+ - Florian Tesson
relevantAbstracts:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
- doi: 10.1093/nar/gkt1419
+ - doi: 10.1128/aem.61.12.4321-4328.1995
---
# AbiE
-AbiE is a family of an anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity.Â
-It is classified as an Abortive infection system.
+## Description
+AbiE was discovered in 1995 on a Lactococcal plasmid :ref{doi=10.1128/aem.61.12.4321-4328.1995} together with AbiF a homolog of [AbiD](/defense-systems/abid)](/defense-systems/abid).
+
+AbiE is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiE is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
+
+AbiE is composed of two proteins: AbiEi and AbiEii. AbiEii is annotated as a nucleotidyltransferase.
## Molecular mechanism
-AbiE systems are encoded by two mandatory genes, abiEi and abiEii (1,2).  The latter encodes for AbiEii, a GTP-binding nucleotidyltransferase (NTase) which expression induce a reversible growth arrest.  On the other hand, abiEi encodes for a AbiEi a transcriptional autorepressor that  binds to the promoter of the abiE operon.
+AbiE is a family of anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity :ref{doi=10.1093/nar/gkt1419}.
+
+AbiEii is a GTP-binding nucleotidyltransferase (NTase) whose expression induces a reversible growth arrest :ref{doi=10.1093/nar/gkt1419}. On the other hand, AbiEi is a transcriptional autorepressor that binds to the promoter of the abiE operon.
+Based on these mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin systems, where the antitoxin and toxin are both proteins that do not directly interact with each other :ref{doi=10.1093/nar/gkt1419}.
-Based on this mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin system, where the antitoxin and toxin are both proteins that do not directly interact with each other.
## Example of genomic structure
--
GitLab