diff --git a/content/3.defense-systems/cbass.md b/content/3.defense-systems/cbass.md index 194fd0de17cdd846d0544547de54b6a32aa760d3..6948cd723a27cf2728c77264e4bbaa5c0582b8e5 100644 --- a/content/3.defense-systems/cbass.md +++ b/content/3.defense-systems/cbass.md @@ -20,6 +20,12 @@ relevantAbstracts: --- # CBASS +## Description + +The CBASS system stands for cyclic oligonucleotide-based antiphage signaling systems :ref{doi=10.1016/j.molcel.2021.10.020}. There are four types and multiple subtypes of characterized CBASS trans membrane systems. Activation of this system results in cell death to prevent phage replication. This system has a shared ancestry with the cGAS-STING innate immune pathway in animals :ref{doi=10.1038/s41564-020-0777-y} +## Molecular mechanism + +CBASS effector proteins limit phage propagation through membrane disruption. When CBASS is activated, Cap15 spreads throughout the cell and causes the inner membrane to rupture :ref{doi=10.1016/j.molcel.2021.10.020} ## Example of genomic structure A total of 4 subsystems have been described for the CBASS system.