From 7e229e8aea96523a796176673968992ac48ab251 Mon Sep 17 00:00:00 2001 From: Lucas PAOLI <lucas.paoli@pasteur.fr> Date: Wed, 22 Nov 2023 15:33:56 +0100 Subject: [PATCH] Update pycsar.md according to Hackaton guidelines, see https://gitlab.pasteur.fr/mdm-lab/wiki/-/issues/227. --- content/3.defense-systems/pycsar.md | 24 ++++++++++++++---------- 1 file changed, 14 insertions(+), 10 deletions(-) diff --git a/content/3.defense-systems/pycsar.md b/content/3.defense-systems/pycsar.md index 9bffd49b..887a0cd2 100644 --- a/content/3.defense-systems/pycsar.md +++ b/content/3.defense-systems/pycsar.md @@ -10,9 +10,23 @@ tableColumns: Activator: Signaling molecules Effector: Membrane disrupting, Nucleotides modifying PFAM: PF00004, PF00027, PF00211, PF00899, PF01734, PF10137, PF14461, PF14464, PF18145, PF18153, PF18303, PF18967 +contributors: + - Lucas Paoli +relevantAbstracts: + - doi: 10.1016/j.cell.2021.09.031 + - doi: 10.1038/s41586-022-04716-y --- # Pycsar + +## Description + +The pyrimidine cyclase system for antiphage resistance (Pycsar) :ref{doi=10.1016/j.cell.2021.09.031}. In turn, phages encode anti-Pycsar (Apic) proteins encoded that counteract Pycsar defenses :ref{doi=10.1038/s41586-022-04716-y} + +## Molecular mechanisms + +Pycsar uses cyclic nucleotide (pyrimidine cyclase) signals to induce cell death via Abi effectors activation and prevent viral propagation, while Apic degrade cyclic nucleotide signals to prevent host immune responses :ref{doi=10.1016/j.cell.2021.09.031,10.1038/s41586-022-04716-y}. + ## Example of genomic structure The Pycsar system is composed of 2 proteins: AG_cyclase and, Effector_TIR. @@ -101,13 +115,3 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.cell.2021.09.031 - ---- -:: - -- GitLab