From 7e229e8aea96523a796176673968992ac48ab251 Mon Sep 17 00:00:00 2001
From: Lucas PAOLI <lucas.paoli@pasteur.fr>
Date: Wed, 22 Nov 2023 15:33:56 +0100
Subject: [PATCH] Update pycsar.md according to Hackaton guidelines, see
 https://gitlab.pasteur.fr/mdm-lab/wiki/-/issues/227.

---
 content/3.defense-systems/pycsar.md | 24 ++++++++++++++----------
 1 file changed, 14 insertions(+), 10 deletions(-)

diff --git a/content/3.defense-systems/pycsar.md b/content/3.defense-systems/pycsar.md
index 9bffd49b..887a0cd2 100644
--- a/content/3.defense-systems/pycsar.md
+++ b/content/3.defense-systems/pycsar.md
@@ -10,9 +10,23 @@ tableColumns:
     Activator: Signaling molecules
     Effector: Membrane disrupting, Nucleotides modifying
     PFAM: PF00004, PF00027, PF00211, PF00899, PF01734, PF10137, PF14461, PF14464, PF18145, PF18153, PF18303, PF18967
+contributors: 
+  - Lucas Paoli
+relevantAbstracts:
+  - doi: 10.1016/j.cell.2021.09.031
+  - doi: 10.1038/s41586-022-04716-y
 ---
 
 # Pycsar
+
+## Description
+
+The pyrimidine cyclase system for antiphage resistance (Pycsar) :ref{doi=10.1016/j.cell.2021.09.031}. In turn, phages encode anti-Pycsar (Apic) proteins encoded that counteract Pycsar defenses :ref{doi=10.1038/s41586-022-04716-y}
+
+## Molecular mechanisms
+
+Pycsar uses cyclic nucleotide (pyrimidine cyclase) signals to induce cell death via Abi effectors activation and prevent viral propagation, while Apic degrade cyclic nucleotide signals to prevent host immune responses :ref{doi=10.1016/j.cell.2021.09.031,10.1038/s41586-022-04716-y}. 
+
 ## Example of genomic structure
 
 The Pycsar system is composed of 2 proteins: AG_cyclase and, Effector_TIR.
@@ -101,13 +115,3 @@ end
     style Title3 fill:none,stroke:none,stroke-width:none
     style Title4 fill:none,stroke:none,stroke-width:none
 </mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
-    - doi: 10.1016/j.cell.2021.09.031
-
----
-::
-
-- 
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