diff --git a/content/3.defense-systems/drt.md b/content/3.defense-systems/drt.md index 3fce08172b854036a62d9d23cdbb40809ce8188a..4297087b3f5db4bd9507e9fdb777c0920136c903 100644 --- a/content/3.defense-systems/drt.md +++ b/content/3.defense-systems/drt.md @@ -10,9 +10,37 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF00078 +contributors: + - Helena Shomar + - Marie Guillaume +relevantAbstracts: + - doi: 10.1093/nar/gkac467 + - doi: 10.1126/science.aba0372 --- # DRT + +## Description +DRT stands for Defense-associated Reverse Transcriptases. +DRTs are a widespread and highly diverse family of defense systems, characterized by reverse transcriptase (RTs) components with antiphage properties. These RTs belong to the so-called group of unknown RTs (UG) and are closely related to the Abortive Infection system (Abi) RTs. + +DRT systems were experimentally validated in _Escherichia coli_ and demonstrated to be effective against an array of diverse phages. +So far, DRTs have been classified in 9 different types. Essential components of each DRT type are: +- DRT Type 1: UG1 (RT-nitrilaseTM domains) +- DRT Type 2: UG2 (RT domain) +- DRT Type 3: UG3 (RT domain), UG8 (RT domain) and ncRNA +- DRT Type 4: UG15 (RT-alphaRep domains) +- DRT Type 5: UG16 (RT domain) +- DRT Type 6: UG12 (RT-alphaRep domains) +- DRT Type 7: UG10 (PrimS-RT-alphaRep domains) +- DRT Type 8: UG7 (RT-alphaRep-PDDExK domains) +- DRT Type 9: UG28 (RT-alphaRep domains) and ncRNA + + +## Molecular mechanism +To our knowledge, the molecular mechanism is unknown. +Similarly, for the other systems of this family, the molecular mechanism remain unknown. + ## Example of genomic structure A total of 9 subsystems have been described for the DRT system. @@ -187,7 +215,7 @@ Escherichia coli Origin_3[ RT UG15 Type 4 Escherichia coli <a href='https://ncbi.nlm.nih.gov/protein/GCK53192.1'>GCK53192.1</a>] --> Expressed_3[Escherichia coli] - Expressed_3[Escherichia coli] ----> T5 & T3 & T7 & Phi-V1 & ZL19 + Expressed_3[Escherichia coli] ----> T5 & T3 & T7 & Phi-V1 & ZL-19 Gao_2020[<a href='https://doi.org/10.1126/science.aba0372'>Gao et al., 2020</a>] --> Origin_4 Origin_4[ RT UG16 Type 5 Escherichia coli @@ -251,12 +279,12 @@ end T3 T7 Phi-V1 - ZL19 + ZL-19 T5 T3 T7 Phi-V1 - ZL19 + ZL-19 T2 T2 T5 @@ -272,14 +300,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1093/nar/gkac467 - - doi: 10.1126/science.aba0372 ---- -::