diff --git a/content/3.defense-systems/septu.md b/content/3.defense-systems/septu.md index 7277766d3231704c71062b47ae5cf9e91c2b973c..d5291d40b2551de4f1237debe5cc8e84f3aa459d 100644 --- a/content/3.defense-systems/septu.md +++ b/content/3.defense-systems/septu.md @@ -10,9 +10,27 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF13175, PF13304, PF13476 +contributors: + - Florian Tesson +relevantAbstracts: + - doi: 10.1016/j.cell.2020.09.065 + - doi: 10.1093/nar/gkab883 + - doi: 10.1126/science.aar4120 --- - # Septu + +## Description +The Septu defense system was discovered in 2018 in *Bacillus* :ref{doi=10.1126/science.aar4120}. The name of the system is related to Septu (or Sopdu) the ancient egypt god of the sky and of eastern border regions. + +The Septu defense systems is composed of two protein PtuA and PtuB: PtuA encoding for an ATPase (AAA15/AAA21) and PtuB with HNH endonuclease domain. + +After the discovery of Septu, two studies discovered separatly another form of Septu :ref{doi=10.1093/nar/gkab883,10.1016/j.cell.2020.09.065}. This new subtype encode a thrid protein with a reverse transcriptase domain. This system is either reffer as Septu Type II :ref{doi=10.1093/nar/gkab883} or as [Retron](/defense-systems/retron) subtype RT-I-A :ref{doi=10.1016/j.cell.2020.09.065,10.1016/j.cell.2020.09.065}. + +The Septu defense system is part of large category of system that encode the AAA15/21 ABC ATPase :ref{doi=10.1111/mmi.15074}. + +## Molecular mechanism +As far as we are aware, the molecular mechanism is unknown. + ## Example of genomic structure The Septu is composed of 2 proteins: PtuA and PtuB. @@ -101,15 +119,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.cell.2020.09.065 - - doi: 10.1093/nar/gkab883 - - doi: 10.1126/science.aar4120 ---- -::