diff --git a/content/3.defense-systems/pycsar.md b/content/3.defense-systems/pycsar.md index b95880865ac8f6d50f880f4d4f369ffefd4c508c..0d9ca792062fa8c35443ce9a332194f120897c51 100644 --- a/content/3.defense-systems/pycsar.md +++ b/content/3.defense-systems/pycsar.md @@ -12,6 +12,7 @@ tableColumns: PFAM: PF00004, PF00027, PF00211, PF00899, PF01734, PF10137, PF14461, PF14464, PF18145, PF18153, PF18303, PF18967 contributors: - Lucas Paoli + - Florian Tesson relevantAbstracts: - doi: 10.1016/j.cell.2021.09.031 - doi: 10.1038/s41586-022-04716-y @@ -21,11 +22,15 @@ relevantAbstracts: ## Description -The pyrimidine cyclase system for antiphage resistance (Pycsar) :ref{doi=10.1016/j.cell.2021.09.031}. In turn, phages encode anti-Pycsar (Apic) proteins encoded that counteract Pycsar defenses :ref{doi=10.1038/s41586-022-04716-y} +The **py**rimidine **c**yclase **s**ystem for **a**ntiphage **r**esistance (Pycsar) :ref{doi=10.1016/j.cell.2021.09.031} is composed of at least two proteins: a cyclase and diverse effectors. The Pycsar defense system is related to the [CBASS](/defense-systems/cbass) but differs in the signaling molecule produced by the cyclase. + +In turn, phages encode anti-Pycsar (Apyc) proteins encoded that counteract Pycsar defenses :ref{doi=10.1038/s41586-022-04716-y}. ## Molecular mechanisms -Pycsar uses cyclic nucleotide (pyrimidine cyclase) signals to induce cell death via Abi effectors activation and prevent viral propagation, while Apic degrade cyclic nucleotide signals to prevent host immune responses :ref{doi=10.1016/j.cell.2021.09.031,10.1038/s41586-022-04716-y}. +Pycsar uses cyclic nucleotide (pyrimidine cyclase, cCMP and cUMP) signals to induce cell death via diverse effectors activation and prevent viral propagation. + +While Apyc degrades cyclic nucleotide signals to prevent host immune responses :ref{doi=10.1016/j.cell.2021.09.031,10.1038/s41586-022-04716-y}. ## Example of genomic structure