From 84abfbcb37c381bd24a3c8623333ce3115cd1127 Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@pasteur.fr>
Date: Tue, 23 Jan 2024 11:41:10 +0100
Subject: [PATCH] merge main and add information
---
content/3.defense-systems/pycsar.md | 9 +++++++--
1 file changed, 7 insertions(+), 2 deletions(-)
diff --git a/content/3.defense-systems/pycsar.md b/content/3.defense-systems/pycsar.md
index b9588086..0d9ca792 100644
--- a/content/3.defense-systems/pycsar.md
+++ b/content/3.defense-systems/pycsar.md
@@ -12,6 +12,7 @@ tableColumns:
PFAM: PF00004, PF00027, PF00211, PF00899, PF01734, PF10137, PF14461, PF14464, PF18145, PF18153, PF18303, PF18967
contributors:
- Lucas Paoli
+ - Florian Tesson
relevantAbstracts:
- doi: 10.1016/j.cell.2021.09.031
- doi: 10.1038/s41586-022-04716-y
@@ -21,11 +22,15 @@ relevantAbstracts:
## Description
-The pyrimidine cyclase system for antiphage resistance (Pycsar) :ref{doi=10.1016/j.cell.2021.09.031}. In turn, phages encode anti-Pycsar (Apic) proteins encoded that counteract Pycsar defenses :ref{doi=10.1038/s41586-022-04716-y}
+The **py**rimidine **c**yclase **s**ystem for **a**ntiphage **r**esistance (Pycsar) :ref{doi=10.1016/j.cell.2021.09.031} is composed of at least two proteins: a cyclase and diverse effectors. The Pycsar defense system is related to the [CBASS](/defense-systems/cbass) but differs in the signaling molecule produced by the cyclase.
+
+In turn, phages encode anti-Pycsar (Apyc) proteins encoded that counteract Pycsar defenses :ref{doi=10.1038/s41586-022-04716-y}.
## Molecular mechanisms
-Pycsar uses cyclic nucleotide (pyrimidine cyclase) signals to induce cell death via Abi effectors activation and prevent viral propagation, while Apic degrade cyclic nucleotide signals to prevent host immune responses :ref{doi=10.1016/j.cell.2021.09.031,10.1038/s41586-022-04716-y}.
+Pycsar uses cyclic nucleotide (pyrimidine cyclase, cCMP and cUMP) signals to induce cell death via diverse effectors activation and prevent viral propagation.
+
+While Apyc degrades cyclic nucleotide signals to prevent host immune responses :ref{doi=10.1016/j.cell.2021.09.031,10.1038/s41586-022-04716-y}.
## Example of genomic structure
--
GitLab