diff --git a/content/3.defense-systems/psyrta.md b/content/3.defense-systems/psyrta.md index 140db84251e537b86a26346d65de7eb6902ad3d7..71dfcf0d3636dee93c08db238f2bfe59c62e37c0 100644 --- a/content/3.defense-systems/psyrta.md +++ b/content/3.defense-systems/psyrta.md @@ -10,9 +10,41 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF00270, PF00271, PF02481, PF04851, PF18306 +contributors: + - Ernest Mordret +relevantAbstracts: + - doi: 10.1016/j.chom.2022.09.017 + - doi: 10.1016/j.molcel.2013.02.002 + - doi: 10.1371/journal.ppat.1005317 --- # PsyrTA + +## Description + +Originally found in a high throughput shotgun cloning of bacterial fragments in E. coli looking for Toxin-Antitoxin pairs. PsyrTA is composed of two proteins, PsyrT, the toxin, is a RecQ family DNA helicase, and PsyrA, the antitoxin, was shown to be a Nucleotide-binding protein. Note that that system is sometimes called RqlHI :ref{doi=10.1371/journal.ppat.1005317}, where RqlH refers to PsyrT and RqlI to PsyrA + +## Molecular mechanisms + +from :ref{doi=10.1016/j.molcel.2013.02.002} : + +> The psyrT shares homology with domains of the RecQ helicase, +> a family of proteins implicated in DNA repair (Bernstein et al., +> 2010); and the antitoxin of the same system, psyrA, has a nucle- +> otide binding domain (COG0758) that was previously described +> in proteins involved in DNA uptake + + +from :ref{doi=10.1016/j.chom.2022.09.017} : + +> Both systems encode an antitoxin +> with homology to DprA, a single-stranded DNA (ssDNA)-binding +> protein known to be involved in DNA transformation (Mortier- +> Barrière et al., 2007). The toxin contains a phosphoribosyl trans- +> ferase (PRTase) domain, which was previously found in effectors +> of retron abortive infection systems " + + ## Example of genomic structure The PsyrTA system is composed of 2 proteins: PsyrT and, PsyrA. @@ -77,14 +109,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.09.017 - - doi: 10.1016/j.molcel.2013.02.002 - ---- ::