From 8a895759d6eb0bca57d5c99b2bdf7ed6826fc7d5 Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Thu, 4 Jan 2024 15:31:59 +0100
Subject: [PATCH] Update abid.md
---
content/3.defense-systems/abid.md | 29 ++++++++++++++++++-----------
1 file changed, 18 insertions(+), 11 deletions(-)
diff --git a/content/3.defense-systems/abid.md b/content/3.defense-systems/abid.md
index f41523d2..a74aaeba 100644
--- a/content/3.defense-systems/abid.md
+++ b/content/3.defense-systems/abid.md
@@ -10,10 +10,28 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF07751
+contributors:
+ - Marian Dominguez-Mirazo
+ - Florian Tesson
+relevantAbstracts:
+ - doi: 10.1023/A:1002027321171
+ - doi: 10.1016/j.mib.2005.06.006
+ - doi: 10.1128/aem.61.5.2023-2026.1995
---
# AbiD
+## Description
+
+AbiD is a single gene system system discovered in may 1995 in the plasmid pBF61 of *Lactococcus lactis* :ref{doi=10.1128/aem.61.5.2023-2026.1995}. An homologs of AbiD, named AbiD1 was discovered in july 1995 :ref{doi=10.1128/jb.177.13.3818-3823.1995}.
+
+AbiD is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiR is classified as possible abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
+
+This antiphage defense system is very close to AbiD1 and AbiF :ref{doi=10.1128/aem.61.12.4321-4328.1995} and are categorized as the same system. Furtheremore, AbiD is also detected as the [Abi2](/defense-systems/abi2) system.
+### Molecular mechanism
+
+For AbiD1 :ref{doi=10.1128/jb.177.13.3824-3829.1995} ([AAA79209](https://www.ncbi.nlm.nih.gov/protein/AAA79209)), the expression of the protein is toxic to the bacteria and is therefore highly regulated. Expression of the protein is triggered by the orf1 of phage bIL66 which results in inhibition of the phage RuvC-like endonuclease activity and stops phage multiplication.
+
## Example of genomic structure
The AbiD is composed of 1 protein: AbiD.
@@ -72,14 +90,3 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
- - doi: 10.1023/A:1002027321171
- - doi: 10.1016/j.mib.2005.06.006
-
----
-::
-
--
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