diff --git a/content/3.defense-systems/prrc.md b/content/3.defense-systems/prrc.md index 105acc2765957ae00466b71f76b31164aafd99ef..7b51d8f5042796081d530d4ca7328c4f1551ab5c 100644 --- a/content/3.defense-systems/prrc.md +++ b/content/3.defense-systems/prrc.md @@ -10,9 +10,25 @@ tableColumns: Activator: Direct Effector: Nucleic acid degrading PFAM: PF00270, PF02384, PF04313, PF04851, PF12008, PF12161, PF13166, PF18766 +contributors: + - Ernest Mordret +relevant abstracts: + - doi: 10.1186/1743-422X-7-360 + - doi: 10.1006/jmbi.1995.0343 --- # PrrC + +## Description + +The PrrC system protects bacteria against phages via an abortive infection. It is composed of a single effector protein, but relies on the presence of a full type Ic restriction-modification system in the vicinity. PrrC proteins are therefore typically found embedded in a larger RM system. + +## Molecular mechanism +The effector protein prrC complements a RM system by cutting tRNALys in the anticodon loop, upstream of the wobble nucleotide and causes the arrest of phage protein synthesis and phage growth. +prrC serves as a guardian of the acrivity of EcoprrI, which can be inactivated by the Stp peptide of phage T4 at the beginning of infection. Inactivation of EcoprrI by Stp induces a conformation change that in turn activates PrrC, releasing its nuclease activity and stalling host and phage growth :ref{doi=10.1006/jmbi.1995.0343}. +Because it sabotages the host's translation machinery, prrC is considered to be an abortive infection system. + + ## Example of genomic structure The PrrC system is composed of 4 proteins: EcoprrI, Type_I_S, PrrC and, Type_I_REases. @@ -78,14 +94,3 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1006/jmbi.1995.0343 - - doi: 10.1186/1743-422X-7-360 - ---- -:: -