From 8f327ccbc2732111cf29c060b72938d9e7565ee0 Mon Sep 17 00:00:00 2001
From: Jean CURY <jean.cury@pasteur.fr>
Date: Fri, 15 Dec 2023 17:46:31 +0100
Subject: [PATCH] Update mmb_gp29_gp30.md
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content/3.defense-systems/mmb_gp29_gp30.md | 2 +-
1 file changed, 1 insertion(+), 1 deletion(-)
diff --git a/content/3.defense-systems/mmb_gp29_gp30.md b/content/3.defense-systems/mmb_gp29_gp30.md
index 1f00506a..3d32e335 100644
--- a/content/3.defense-systems/mmb_gp29_gp30.md
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tableColumns:
article:
doi: 10.1038/nmicrobiol.2016.251
- abstract:
+ abstract: |
Temperate phages are common, and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage. Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defence systems include a single-subunit restriction system, a heterotypic exclusion system and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, which acts as a highly effective counter-defence system. Prophage-mediated viral defence offers an efficient mechanism for bacterial success in host-virus dynamics, and counter-defence promotes phage co-evolution.
contributors:
- Hugo Vaysset
--
GitLab