From 9204dab2fd73df61ac9407b689ba07b23bc47203 Mon Sep 17 00:00:00 2001
From: "Gemma C. Atkinson" <gemma.atkinson@med.lu.se>
Date: Mon, 22 Jan 2024 09:19:23 +0100
Subject: [PATCH] Update rosmerta.md
---
content/3.defense-systems/rosmerta.md | 28 +++++++++++++++++++++++++--
1 file changed, 26 insertions(+), 2 deletions(-)
diff --git a/content/3.defense-systems/rosmerta.md b/content/3.defense-systems/rosmerta.md
index db5e5087..b8aef238 100644
--- a/content/3.defense-systems/rosmerta.md
+++ b/content/3.defense-systems/rosmerta.md
@@ -24,11 +24,11 @@ The RosmerTA system was found to have antiviral activity and named after Gallo-R
## Molecular mechanisms
-The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function :ref{doi=10.1016/j.chom.2022.09.017} and was later found to induce membrane depolarization :ref{doi=10.1073/pnas.2305393120}.
+The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function :ref{doi=10.1016/j.chom.2022.09.017}. One toxin representative has been found to induce membrane depolarization :ref{doi=10.1073/pnas.2305393120}.
## Example of genomic structure
-The RosmerTA is composed of 2 proteins: RmrT and RmrA.
+The RosmerTA is composed of 2 proteins: RmrT and RmrA. The toxin can vary in sequence and structure.
Here is an example found in the RefSeq database:
@@ -88,3 +88,27 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
+<mermaid>
+graph LR;
+ Ernits_2023[<a href='https://www.pnas.org/doi/10.1073/pnas.2305393120'>Ernits et al., 2023</a>] --> Origin_0
+ Origin_0[Gordonia phage Kita
+<a href='https://www.ncbi.nlm.nih.gov/protein/YP_009301394.1/'>YP_009301394.1</a>, <a href='https://www.ncbi.nlm.nih.gov/protein/YP_009301394.1'>YP_009301394.1</a>] --> Expressed_0[Escherichia coli]
+ Expressed_0[Escherichia coli] ----> Bas54 and Bas59
+ subgraph Title1[Reference]
+ Ernits_2023
+end
+ subgraph Title2[System origin]
+ Origin_0
+end
+ subgraph Title3[Expression species]
+ Expressed_0
+end
+ subgraph Title4[Phage infected]
+ Bas54
+ Bas59
+end
+ style Title1 fill:none,stroke:none,stroke-width:none
+ style Title2 fill:none,stroke:none,stroke-width:none
+ style Title3 fill:none,stroke:none,stroke-width:none
+ style Title4 fill:none,stroke:none,stroke-width:none
+</mermaid>
--
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