From 96da995bce194e23d94a73eb44bc0eeb63e2d628 Mon Sep 17 00:00:00 2001
From: hvaysset <hugo.vaysset@cri-paris.org>
Date: Tue, 16 Jan 2024 09:36:45 +0100
Subject: [PATCH] Update pd-t7-5.md
---
content/3.defense-systems/pd-t7-5.md | 15 +++++++++++----
1 file changed, 11 insertions(+), 4 deletions(-)
diff --git a/content/3.defense-systems/pd-t7-5.md b/content/3.defense-systems/pd-t7-5.md
index 1b97e8c5..7d2dbf89 100644
--- a/content/3.defense-systems/pd-t7-5.md
+++ b/content/3.defense-systems/pd-t7-5.md
@@ -9,14 +9,22 @@ tableColumns:
Sensor: Unknown
Activator: Unknown
Effector: Unknown
+contributors:
+ - Hugo Vaysset
relevantAbstracts:
- - doi: 10.1038/s41564-022-01219-4
+ - doi: 10.1038/s41564-022-01219-4
---
# PD-T7-5
-## Example of genomic structure
-The PD-T7-5 is composed of 1 protein: PD-T7-5.
+## Description
+PD-T7-5 is a defense system composed of a single protein which was discovered in :ref{doi=10.1038/s41564-022-01219-4}. Its antiphage activity was assessed by heterologous expression in *E. coli* against T7 and to reduce the size of lysis plaques of T3 :ref{doi=10.1038/s41564-022-01219-4}. PD-T7-5 contains a PD(D/E)XK nuclease domain like [PD-T7-1](/defense-systems/pd-t7-1).
+
+## Molecular mechanism
+As far as we are aware, the molecular mechanism is unknown. However, the presence of a PD(D/E)XK domain in PD-T7-5 suggests a mechanism of action via DNA degradation :ref{doi=10.1038/s41564-022-01219-4}.
+
+## Example of genomic structure
+The PD-T7-5 system is composed of one protein: PD-T7-5.
Here is an example found in the RefSeq database:
@@ -76,4 +84,3 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-
--
GitLab