diff --git a/content/3.defense-systems/sanata.md b/content/3.defense-systems/sanata.md index 1a7f6d2ff8582a5168c40f9242234e6d8b7c1a3b..5fc9a496e876a4981119ea0836cf04c513a8026c 100644 --- a/content/3.defense-systems/sanata.md +++ b/content/3.defense-systems/sanata.md @@ -10,9 +10,23 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF08843 +contributors: + - Alba Herrero del Valle + +relevantAbstracts: + - doi: 10.1016/j.molcel.2013.02.002 --- # SanaTA + +## Description + +The SanaTA system is composed of 2 proteins: SanaT and, SanaA, where SanaT encodes a toxin and SanaA encodes an antitoxin to form a toxin-antitoxin (TA) system. The toxin protein, SanaT, contains a Nucleotidyl transferase domain (PF08843). This system provides resistance against mutated T7 phages that lack the nonessential 4.5 gene in *Shewanella sp.* ANA-3. Sberro et al. showed that the defensiveness of sanaTA depends on the cleavage of SanaA by the Lon system, a protease that degrades the antitoxin to allow the activity of the toxin :ref{doi=10.1016/j.molcel.2013.02.002}. + +## Molecular mechanism + +It has been shown to function as a toxin-antitoxin (TA) system. + ## Example of genomic structure The SanaTA system is composed of 2 proteins: SanaT and, SanaA. @@ -75,13 +89,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.molcel.2013.02.002 ---- -::